CPPF services include:
- Pharmacokinetics, including assay development, validation, identification and/or quantitation of drugs, metabolites, metabolizing enzymes, and other endogenous products in biological matrices, and PK analysis/modeling. View the list of PK assays offered by the CPPF.
- Pharmacodynamics, including assay development, validation, and sample analysis.
- Consultation, aiding investigators in the experimental design of studies involving analytical chemical, PK, or PD efforts, and liaising with existing facilities and investigators to minimize financial costs and maximize scientific revenue for each project.
- Integration, performing PK/PD correlations and correlating PK or PD metrics with clinical outcomes.
Services are evaluated on a regular basis to assess levels of scientific demand, potential benefits of research, and financial feasibility. The facility encourages suggestions and requests for new assays or instrumentation from investigators that require additional support for their research activities. The CPPF attempts to maintain maximum flexibility, and is eager to work with individuals on special project needs that are not necessarily regular activities within the facility. The CPPF strives to support and enhance the research environment; every effort is made to acquire new instrumentation, software, or capabilities as the field of analytical chemistry and pharmacokinetics advances in technique and concept.
Major Analytical Chemical Instrumentation
|2x LC-MS:||Thermo Finnigan MSQ mass spectrometer Agilent model 1100 binary pump, and autosampler, operated under Thermo Finnigan Excalibur software.|
|4x LC-MS/MS:||Waters QuattroMicro triple stage mass spectrometer, Agilent model 1100 binary pump and autosampler, operated under Masslynx version 4.0.|
|1x LC-MS/MS:||Applied Biosystems 4000Q hybrid triple-quadrupole, linear ion-trap mass spectrometer, Agilent model 1200 binary pump, autosampler, diode array detector, and column thermostat.|
|1x COBAS1:||Roche Cobas C111 Clinical Chemistry analyzer.|
|1x HPLC:||Agilent 1100 series G1379A degasser, G1311A quaternary pump, G1313A ALS autosampler, G1314 F 1260 VWD variable wavelength detector, Chemstation software.|
|1x HPLC:||Alliance Waters 2695 separation module, model 2487 dual lambda absorbance detector, Waters 996 photodiode array detector, Masslynx software.|
|1x HPLC:||Beckman System Gold 508 autosampler, 166 UV detector, 126 solvent module, and IN/US beta-ram model 2B flow-through radio-isotope detector/fluorescence detector.|
|1x AAS:||Perkin-Elmer model AAnalyst 600 atomic absorption spectrometer with THGA graphite tube furnace, AS 800 furnace autosampler.|
|IR scanner:||Odyssey infrared dual-wavelength scanner.|
|Tecan:||Multifunction Tecan Safire2 plate reader.|