. Next-Generation Replication-Defective HSV Vectors for Delivery of Large DNA Payloads. Mol Ther. 2025-05-07; doi: 10.1016/j.ymthe.2025.03.055. nihFormattedCitation: Ingusci S, Goins WF, Cohen JB, Miyagawa Y, Knipe DM, Glorioso JC. Next-Generation Replication-Defective HSV Vectors for Delivery of Large DNA Payloads. Mol Ther. 2025;.. PubMed PMID: 40181547.
. Celebrating 25 years of Molecular Therapy. Mol Ther. 2025-05-07; doi: 10.1016/j.ymthe.2025.03.059. nihFormattedCitation: Glorioso JC. Celebrating 25 years of Molecular Therapy. Mol Ther. 2025;.. PubMed PMID: 40233755.
. High IgG titers against EBV glycoprotein 42 correlate with lower risk of nasopharyngeal carcinoma. J Clin Invest. 2025-02-17;135(4): doi: 10.1172/JCI189207. nihFormattedCitation: Warner BE, Shair KH. High IgG titers against EBV glycoprotein 42 correlate with lower risk of nasopharyngeal carcinoma. J Clin Invest. 2025;135(4). PMCID: PMC11827836.. PubMed PMID: 39959976; PMCID: PMC11827836.
. The Epstein-Barr virus nuclear antigen 1 variant associated with nasopharyngeal carcinoma defines the sequence criteria for serologic risk prediction. Clin Cancer Res. 2024-11-15; doi: 10.1158/1078-0432.CCR-24-1142. nihFormattedCitation: Warner BE, Patel J, Wang R, Adams-Haduch J, Gao YT, Koh WP, Wong KW, Chiang AKS, Yuan JM, Shair KHY. The Epstein-Barr virus nuclear antigen 1 variant associated with nasopharyngeal carcinoma defines the sequence criteria for serologic risk prediction. Clin Cancer Res. 2024;. PMCID: PMC11567791.. PubMed PMID: 39264275; PMCID: PMC11567791.
. The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation. Immunity. 2024-08-13; doi: 10.1016/j.immuni.2024.06.003. nihFormattedCitation: Harioudh MK, Perez J, So L, Maheshwari M, Ebert TS, Hornung V, Savan R, Rouf Banday A, Diamond MS, Rathinam VA, Sarkar SN. The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation. Immunity. 2024;. PMCID: PMC11324410.. PubMed PMID: 38955184; PMCID: PMC11324410.
. Targeted eradication of EBV-positive cancer cells by CRISPR/dCas9-mediated EBV reactivation in combination with ganciclovir. mBio. 2024-07-17;e0079524. doi: 10.1128/mbio.00795-24. nihFormattedCitation: Sugiokto FG, Li R. Targeted eradication of EBV-positive cancer cells by CRISPR/dCas9-mediated EBV reactivation in combination with ganciclovir. mBio. 2024;:e0079524. PMCID: PMC11253602.. PubMed PMID: 38874417; PMCID: PMC11253602.
. NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits. Cell Host Microbe. 2024-06-12; doi: 10.1016/j.chom.2024.04.014. nihFormattedCitation: Shang P, Dos Santos Natividade R, Taylor GM, Ray A, Welsh OL, Fiske KL, Sutherland DM, Alsteens D, Dermody TS. NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits. Cell Host Microbe. 2024;. PMCID: PMC11176008.. PubMed PMID: 38729153; PMCID: PMC11176008.
. An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T cells and Promotes Tumor Clearance. Cancer Immunol Res. 2024-06-04; doi: 10.1158/2326-6066.CIR-23-0573. nihFormattedCitation: Shao L, Srivastava R, Delgoffe GM, Thorne SH, Sarkar SN. An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T cells and Promotes Tumor Clearance. Cancer Immunol Res. 2024;. PMCID: PMC11150089.. PubMed PMID: 38517470; PMCID: PMC11150089.
. Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production. Immunity. 2024-03-12;57(3):446-461.e7. doi: 10.1016/j.immuni.2024.02.002. nihFormattedCitation: Harioudh MK, Perez J, Chong Z, Nair S, So L, McCormick KD, Ghosh A, Shao L, Srivastava R, Soveg F, Ebert TS, Atianand MK, Hornung V, Savan R, Diamond MS, Sarkar SN. Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production. Immunity. 2024;57(3):446-461.e7. PMCID: PMC10939734.. PubMed PMID: 38423012; PMCID: PMC10939734.
. SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication. mBio. 2024-02-14;e0316823. doi: 10.1128/mbio.03168-23. nihFormattedCitation: Sugiokto FG, Saiada F, Zhang K, Li R. SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication. mBio. 2024;:e0316823. PMCID: PMC10865817.. PubMed PMID: 38236021; PMCID: PMC10865817.
. Hepatitis B virus-related hepatocellular carcinoma exhibits distinct intratumoral microbiota and immune microenvironment signatures. J Med Virol. 2024-02-01;96(2):e29485. doi: 10.1002/jmv.29485. nihFormattedCitation: Liu Y, Kim ES, Guo H. Hepatitis B virus-related hepatocellular carcinoma exhibits distinct intratumoral microbiota and immune microenvironment signatures. J Med Virol. 2024;96(2):e29485. PMCID: PMC10916714.. PubMed PMID: 38377167; PMCID: PMC10916714.
. Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases. Proc Natl Acad Sci U S A. 2023-12-19;120(51):e2316467120. doi: 10.1073/pnas.2316467120. nihFormattedCitation: Peng WY, Abere B, Shi H, Toland S, Smithgall TE, Moore PS, Chang Y. Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases. Proc Natl Acad Sci U S A. 2023;120(51):e2316467120. PMCID: PMC10740393.. PubMed PMID: 38079542; PMCID: PMC10740393.
. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle. Cell Death Dis. 2023-09-06;14(9):591. doi: 10.1038/s41419-023-06121-3. nihFormattedCitation: Zhang X, Meng W, Feng J, Gao X, Qin C, Feng P, Huang Y, Gao SJ. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle. Cell Death Dis. 2023;14(9):591. PMCID: PMC10482891.. PubMed PMID: 37673880; PMCID: PMC10482891.
. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023-07-25;120(30):e2308010120. doi: 10.1073/pnas.2308010120. nihFormattedCitation: Wan L, Toland S, Robinson-McCarthy LR, Lee N, Schaich MA, Hengel SR, Li X, Bernstein KA, Van Houten B, Chang Y, Moore PS. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023;120(30):e2308010120. PMCID: PMC10372695.. PubMed PMID: 37459531; PMCID: PMC10372695.
. Long-acting antiretrovirals and HIV treatment adherence. Lancet HIV. 2023-05-01;10(5):e332-e342. doi: 10.1016/S2352-3018(23)00051-6. nihFormattedCitation: Nachega JB, Scarsi KK, Gandhi M, Scott RK, Mofenson LM, Archary M, Nachman S, Decloedt E, Geng EH, Wilson L, Rawat A, Mellors JW. Long-acting antiretrovirals and HIV treatment adherence. Lancet HIV. 2023;10(5):e332-e342. PMCID: PMC10734401.. PubMed PMID: 37062293; PMCID: PMC10734401.
. Characterization of Viruses in Phase 3 and Phase 3b Trials (the Ring Study and the Dapivirine Ring Extended Access and Monitoring Trial) of the Dapivirine Vaginal Ring for Human Immunodeficiency Virus Type 1 Infection Risk Reduction. Clin Infect Dis. 2023-03-21;76(6):996-1002. doi: 10.1093/cid/ciac875. nihFormattedCitation: Steytler J, Craig C, van der Ryst E, Van Baelen B, Nuttall J, van Niekerk N, Mellors J, Parikh U, Wallis C, Ring Study and the DREAM Trial Study Teams. Characterization of Viruses in Phase 3 and Phase 3b Trials (the Ring Study and the Dapivirine Ring Extended Access and Monitoring Trial) of the Dapivirine Vaginal Ring for Human Immunodeficiency Virus Type 1 Infection Risk Reduction. Clin Infect Dis. 2023;76(6):996-1002.. PubMed PMID: 36345569.
. Clinical Presentation, Treatment Response, and Virology Outcomes of Women Who Seroconverted in the Dapivirine Vaginal Ring Trials-The Ring Study and DREAM. Clin Infect Dis. 2023-02-08;76(3):389-397. doi: 10.1093/cid/ciac804. nihFormattedCitation: Steytler J, van der Ryst E, Craig C, Van Baelen B, Nuttall J, van Niekerk N, Mellors J, Parikh U, Wallis C, IPM 007 Study Team. Clinical Presentation, Treatment Response, and Virology Outcomes of Women Who Seroconverted in the Dapivirine Vaginal Ring Trials-The Ring Study and DREAM. Clin Infect Dis. 2023;76(3):389-397. PMCID: PMC10169386.. PubMed PMID: 36189636; PMCID: PMC10169386.
. Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp). J Med Virol. 2023-01-01;95(1):e28246. doi: 10.1002/jmv.28246. nihFormattedCitation: Meng W, Guo S, Cao S, Shuda M, Robinson-McCarthy LR, McCarthy KR, Shuda Y, Paniz Mondolfi AE, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Li P, Zhang H, Perlman S, Guo H, Gao SJ, Chang Y, Moore PS. Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp). J Med Virol. 2023;95(1):e28246. PMCID: PMC9874566.. PubMed PMID: 36271490; PMCID: PMC9874566.
. Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma. Clin Cancer Res. 2022-12-01;28(23):5221-5230. doi: 10.1158/1078-0432.CCR-22-1600. nihFormattedCitation: Paudel S, Warner BE, Wang R, Adams-Haduch J, Reznik AS, Dou J, Huang Y, Gao YT, Koh WP, Bäckerholm A, Yuan JM, Shair KHY. Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma. Clin Cancer Res. 2022;28(23):5221-5230. PMCID: PMC9722633.. PubMed PMID: 36165913; PMCID: PMC9722633.
. Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies. Clin Infect Dis. 2022-03-09;74(5):865-870. doi: 10.1093/cid/ciab541. nihFormattedCitation: Li JZ, Aga E, Bosch RJ, Pilkinton M, Kroon E, MacLaren L, Keefer M, Fox L, Barr L, Acosta E, Ananworanich J, Coombs R, Mellors JW, Landay AL, Macatangay B, Deeks S, Gandhi RT, Smith DM. Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies. Clin Infect Dis. 2022;74(5):865-870. PMCID: PMC8906742.. PubMed PMID: 34117753; PMCID: PMC8906742.
. m6A-express: uncovering complex and condition-specific m6A regulation of gene expression. Nucleic Acids Res. 2021-11-18;49(20):e116. doi: 10.1093/nar/gkab714. nihFormattedCitation: Zhang T, Zhang SW, Zhang SY, Gao SJ, Chen Y, Huang Y. m6A-express: uncovering complex and condition-specific m6A regulation of gene expression. Nucleic Acids Res. 2021;49(20):e116. PMCID: PMC8599805.. PubMed PMID: 34417605; PMCID: PMC8599805.
. Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas. Sci Adv. 2021-10-15;7(42):eabi8795. doi: 10.1126/sciadv.abi8795. nihFormattedCitation: Mellors JW, Guo S, Naqvi A, Brandt LD, Su L, Sun Z, Joseph KW, Demirov D, Halvas EK, Butcher D, Scott B, Hamilton A, Heil M, Karim B, Wu X, Hughes SH. Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas. Sci Adv. 2021;7(42):eabi8795. PMCID: PMC8514100.. PubMed PMID: 34644108; PMCID: PMC8514100.
. Ins and Outs of Reovirus: Vesicular Trafficking in Viral Entry and Egress. Trends Microbiol. 2021-04-01;29(4):363-375. doi: 10.1016/j.tim.2020.09.004. nihFormattedCitation: Roth AN, Aravamudhan P, Fernández de Castro I, Tenorio R, Risco C, Dermody TS. Ins and Outs of Reovirus: Vesicular Trafficking in Viral Entry and Egress. Trends Microbiol. 2021;29(4):363-375. PMCID: PMC7523517.. PubMed PMID: 33008713; PMCID: PMC7523517.
. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Nat Commun. 2021-02-16;12(1):1055. doi: 10.1038/s41467-021-21206-3. nihFormattedCitation: Li T, Wang X, Ju E, da Silva SR, Chen L, Zhang X, Wei S, Gao SJ. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Nat Commun. 2021;12(1):1055. PMCID: PMC7887217.. PubMed PMID: 33594058; PMCID: PMC7887217.
. Proteomic approach to discover human cancer viruses from formalin-fixed tissues. JCI Insight. 2020-11-19;5(22): doi: 10.1172/jci.insight.143003. nihFormattedCitation: Toptan T, Cantrell PS, Zeng X, Liu Y, Sun M, Yates NA, Chang Y, Moore PS. Proteomic approach to discover human cancer viruses from formalin-fixed tissues. JCI Insight. 2020;5(22). PMCID: PMC7710300.. PubMed PMID: 33055416; PMCID: PMC7710300.
. HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus. J Clin Invest. 2020-11-02;130(11):5847-5857. doi: 10.1172/JCI138099. nihFormattedCitation: Halvas EK, Joseph KW, Brandt LD, Guo S, Sobolewski MD, Jacobs JL, Tumiotto C, Bui JK, Cyktor JC, Keele BF, Morse GD, Bale MJ, Shao W, Kearney MF, Coffin JM, Rausch JW, Wu X, Hughes SH, Mellors JW. HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus. J Clin Invest. 2020;130(11):5847-5857. PMCID: PMC7598056.. PubMed PMID: 33016926; PMCID: PMC7598056.
. Diverse Human Immunodeficiency Virus-1 Drug Resistance Profiles at Screening for ACTG A5288: A Study of People Experiencing Virologic Failure on Second-line Antiretroviral Therapy in Resource-limited Settings. Clin Infect Dis. 2020-10-23;71(7):e170-e177. doi: 10.1093/cid/ciz1116. nihFormattedCitation: Wallis CL, Hughes MD, Ritz J, Viana R, de Jesus CS, Saravanan S, van Schalkwyk M, Mngqibisa R, Salata R, Mugyenyi P, Hogg E, Hovind L, Wieclaw L, Gross R, Godfrey C, Collier AC, Grinsztejn B, Mellors JW. Diverse Human Immunodeficiency Virus-1 Drug Resistance Profiles at Screening for ACTG A5288: A Study of People Experiencing Virologic Failure on Second-line Antiretroviral Therapy in Resource-limited Settings. Clin Infect Dis. 2020;71(7):e170-e177. PMCID: PMC7583422.. PubMed PMID: 31724034; PMCID: PMC7583422.
. Better Biomarkers for Surgeons Treating Cancer. JAMA Surg. 2020-07-01;155(7):580. doi: 10.1001/jamasurg.2020.1134. nihFormattedCitation: Bartlett DL. Better Biomarkers for Surgeons Treating Cancer. JAMA Surg. 2020;155(7):580.. PubMed PMID: 32520321.
. Chikungunya virus replication in skeletal muscle cells is required for disease development. J Clin Invest. 2020-03-02;130(3):1466-1478. doi: 10.1172/JCI129893. nihFormattedCitation: Lentscher AJ, McCarthy MK, May NA, Davenport BJ, Montgomery SA, Raghunathan K, McAllister N, Silva LA, Morrison TE, Dermody TS. Chikungunya virus replication in skeletal muscle cells is required for disease development. J Clin Invest. 2020;130(3):1466-1478. PMCID: PMC7269570.. PubMed PMID: 31794434; PMCID: PMC7269570.
. Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety. J Immunother Cancer. 2020-03-01;8(1): doi: 10.1136/jitc-2020-000710. nihFormattedCitation: Ge Y, Wang H, Ren J, Liu W, Chen L, Chen H, Ye J, Dai E, Ma C, Ju S, Guo ZS, Liu Z, Bartlett DL. Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety. J Immunother Cancer. 2020;8(1). PMCID: PMC7103801.. PubMed PMID: 32209602; PMCID: PMC7103801.
. Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis. J Clin Invest. 2019-07-15;129(8):3310-3323. doi: 10.1172/JCI127166. nihFormattedCitation: Li T, Ju E, Gao SJ. Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis. J Clin Invest. 2019;129(8):3310-3323. PMCID: PMC6668677.. PubMed PMID: 31305263; PMCID: PMC6668677.
. Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance. J Clin Invest. 2019-07-15;129(8):3339-3346. doi: 10.1172/JCI127413. nihFormattedCitation: Spudich S, Robertson KR, Bosch RJ, Gandhi RT, Cyktor JC, Mar H, Macatangay BJ, Lalama CM, Rinaldo C, Collier AC, Godfrey C, Eron JJ, McMahon D, Jacobs JL, Koontz D, Hogg E, Vecchio A, Mellors JW. Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance. J Clin Invest. 2019;129(8):3339-3346. PMCID: PMC6668666.. PubMed PMID: 31305262; PMCID: PMC6668666.
. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Immunity. 2019-01-15;50(1):51-63.e5. doi: 10.1016/j.immuni.2018.12.013. nihFormattedCitation: Ghosh A, Shao L, Sampath P, Zhao B, Patel NV, Zhu J, Behl B, Parise RA, Beumer JH, O'Sullivan RJ, DeLuca NA, Thorne SH, Rathinam VAK, Li P, Sarkar SN. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Immunity. 2019;50(1):51-63.e5. PMCID: PMC6342484.. PubMed PMID: 30635239; PMCID: PMC6342484.
. Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics. J Immunother Cancer. 2019-01-09;7(1):6. doi: 10.1186/s40425-018-0495-7. nihFormattedCitation: Guo ZS, Lu B, Guo Z, Giehl E, Feist M, Dai E, Liu W, Storkus WJ, He Y, Liu Z, Bartlett DL. Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics. J Immunother Cancer. 2019;7(1):6. PMCID: PMC6325819.. PubMed PMID: 30626434; PMCID: PMC6325819.
. Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2. Nat Commun. 2018-11-08;9(1):4682. doi: 10.1038/s41467-018-06954-z. nihFormattedCitation: Liu Z, Ge Y, Wang H, Ma C, Feist M, Ju S, Guo ZS, Bartlett DL. Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2. Nat Commun. 2018;9(1):4682. PMCID: PMC6224581.. PubMed PMID: 30410056; PMCID: PMC6224581.
. Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade. Mol Ther. 2018-10-03;26(10):2476-2486. doi: 10.1016/j.ymthe.2018.07.013. nihFormattedCitation: Kowalsky SJ, Liu Z, Feist M, Berkey SE, Ma C, Ravindranathan R, Dai E, Roy EJ, Guo ZS, Bartlett DL. Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade. Mol Ther. 2018;26(10):2476-2486. PMCID: PMC6171074.. PubMed PMID: 30064894; PMCID: PMC6171074.
