Faculty

Co-Directors

Steffi Oesterreich

Steffi Oesterreich

Program: Cancer Biology

oesterreichs@upmc.edu B411 Magee-Womens Research Institute
204 Craft Avenue
Pittsburgh PA
Summary

The main interest of Dr. Oesterreich's laboratory is to further our understanding of hormone action in women's cancers (including both breast and ovarian cancers), with the ultimate goal to use this knowledge for improved diagnosis and endocrine treatment. These studies include many aspects of translational breast cancer research utilizing basic biochemistry, molecular and cell biology, and cell lines, mouse models and clinical samples. Over the last few years, Dr. Oesterreich has developed a strong research interest in in situ and invasive lobular disease, the second most common yet understudied histological subtype of breast cancer. In her role as Director of Education at the Women's Cancer Research Center, Dr. Oesterreich is also very interested in providing outstanding training opportunities to the next generation of women's cancer researchers.

Research Interests and Keywords
  • breast cancer
  • ovarian cancer
  • estrogen receptor
  • invasive lobular carcinoma
  • epigenetics
  • chromatin
  • coregulators
  • bone metastases
  • lobular carcinoma in situ
  • mutations
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Ronald Buckanovich

Ronald Buckanovich

Program: Cancer Biology

412-641-4721 buckanovichrj@mwri.magee.edu 204 Craft Avenue, B333
Pittsburgh PA
Summary

Cancer stem cells (CSC) are rare, inherently chemoresistant cells, which have the capacity to differentiate and generate the numerous cancer cell types observed in a tumor. CSC are hypothesized to be the primary source of cancer recurrence and ultimately a patient's demise. The primary objective of my laboratory is to understand cellular interactions in the tumor vascular/cancer stem cell niche with the goal of developing novel therapeutics targeting CSC proliferation and differentiation. In order to characterize these interactions, we have performed an extensive characterization of ovarian CSC and have begun to define a differentiation hierarchy of the ovarian CSC. In addition, we have characterized several components of the ovarian CSC niche; we have extensively characterized the ovarian tumor vasculature, tumor vascular associated leukocytes, and cancer associated mesenchymal stem cells. We have developed novel in vitro microfluidics devices as a means to study symmetric versus asymmetric divisions of CSC, and novel human in vivo tumor models for the study of ovarian CSC growth and differentiation. Finally, we have developed tumor vascular niche targeted nanoparticle platform with which to assess the efficacy of CSC targeted therapies delivered specifically to CSC. We are now perfectly placed to significantly develop the field of cancer stem cell based differentiation targeted therapies.

Research Interests and Keywords
  • Ovarian cancer
  • cancer stem cells
  • tumor vasculature
  • targeted therapies
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