Selected Member Publications

NIH Citation: Lazare S, Gu Z, Earland N, Harmon MA, Pacula M, Rivera M, Tellis A, Whitfield D, Benson A, Gerndt S, Harris P, Khalil L, Ramirez R, Xu Z, Wahle B, Puram S, Adkins D, Thorstad W, Zandberg D, Chernock R, Skinner H, Spector ME, Seethala R, Ferris RL, Smith JD, Greer AE, Verner EL, Georgiadis A, Sausen M, Ramkissoon SH, Jensen TJ, Francis MS, Winckler W, Chaudhuri AA, Zevallos JP. Postoperative Lymph is a Proximal Source of ctDNA for Detection of Recurrence in HPV-independent Head and Neck Cancer. Clin Cancer Res. 2025;.

NIH Citation: Levitt RC, Kandel MB, Zhuang GZ, Goins WF, Sarantopoulos KD, Glorioso JC. Biosafety and Efficacy of Kv7 Activating rdHSV-CA8* Analgesic Gene Therapy for Chronic Pain Via the Intra-Articular Route in Mice. Mol Ther. 2025;. PMCID: PMC12432987.

NIH Citation: Zandberg DP, Vujanovic L, Clump DA, Isett BP, Wang H, Sica G, Bao R, Li H, Ohr J, Skinner HD, Seethala RR, Chiosea SI, Ferris RL, Bauman JE. Randomized Phase II Study of Concurrent Versus Sequential Pembrolizumab in Combination With Chemoradiation in Locally Advanced Head and Neck Cancer. J Clin Oncol. 2025;:JCO2401580. PMCID: PMC12316147.

NIH Citation: Zandberg DP, Allred JB, Rosenberg AJ, Kaczmar JM, Swiecicki P, Julian RA, Poklepovic AS, Bauman JR, Phan MD, Saba NF, Rivera E, Rowland K, Davar D, Cordes J, Ho AL, Zhang M, Berg SA, Munster PN, Schwartz GK. Phase II (Alliance A091802) Randomized Trial of Avelumab Plus Cetuximab Versus Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma. J Clin Oncol. 2025;:JCO2500759.

NIH Citation: Glorioso JC. Celebrating 25 years of Molecular Therapy. Mol Ther. 2025;. PMCID: PMC12126797.

NIH Citation: Ingusci S, Goins WF, Cohen JB, Miyagawa Y, Knipe DM, Glorioso JC. Next-Generation Replication-Defective HSV Vectors for Delivery of Large DNA Payloads. Mol Ther. 2025;. PMCID: PMC12126788.

NIH Citation: Charette M, Rosenblum C, Shade O, Deiters A. Optogenetics with Atomic Precision─A Comprehensive Review of Optical Control of Protein Function through Genetic Code Expansion. Chem Rev. 2025;. PMCID: PMC11869211.

NIH Citation: Warner BE, Shair KH. High IgG titers against EBV glycoprotein 42 correlate with lower risk of nasopharyngeal carcinoma. J Clin Invest. 2025;135(4). PMCID: PMC11827836.

NIH Citation: Duncan AW. Pathological polyploidy and liver repair failure in RAD51-deficient mice. Hepatology. 2025;. PMCID: PMC12036278.

NIH Citation: Warner BE, Patel J, Wang R, Adams-Haduch J, Gao YT, Koh WP, Wong KW, Chiang AKS, Yuan JM, Shair KHY. The Epstein-Barr virus nuclear antigen 1 variant associated with nasopharyngeal carcinoma defines the sequence criteria for serologic risk prediction. Clin Cancer Res. 2024;. PMCID: PMC11567791.

NIH Citation: Harioudh MK, Perez J, So L, Maheshwari M, Ebert TS, Hornung V, Savan R, Rouf Banday A, Diamond MS, Rathinam VA, Sarkar SN. The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation. Immunity. 2024;57(8):1812-1827.e7. PMCID: PMC11324410.

NIH Citation: Shang P, Dos Santos Natividade R, Taylor GM, Ray A, Welsh OL, Fiske KL, Sutherland DM, Alsteens D, Dermody TS. NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits. Cell Host Microbe. 2024;. PMCID: PMC11176008.

NIH Citation: Earland N, Semenkovich NP, Ramirez RJ, Gerndt SP, Harris PK, Gu Z, Hearn AI, Inkman M, Szymanski JJ, Whitfield D, Wahle BM, Xu Z, Chen K, Alahi I, Ni G, Chen A, Winckler W, Zhang J, Chaudhuri AA, Zevallos JP. Sensitive MRD detection from lymphatic fluid after surgery in HPV-associated oropharyngeal cancer. Clin Cancer Res. 2024;. PMCID: PMC10982646.

NIH Citation: Harioudh MK, Perez J, Chong Z, Nair S, So L, McCormick KD, Ghosh A, Shao L, Srivastava R, Soveg F, Ebert TS, Atianand MK, Hornung V, Savan R, Diamond MS, Sarkar SN. Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production. Immunity. 2024;57(3):446-461.e7. PMCID: PMC10939734.

NIH Citation: Rammal R, Wasserman JK, Singhi AD, Griffith CC, Seethala RR. Glomangiosarcoma-like Anaplastic Transformation in Papillary Thyroid Carcinoma: A Novel Form of Heterologous Differentiation and a Systematic Review of Heterologous Element Prevalence. Endocr Pathol. 2023;.

NIH Citation: Albright S, Cacace M, Tivon Y, Deiters A. Cell Surface Labeling and Detection of Protein Tyrosine Kinase 7 via Covalent Aptamers. J Am Chem Soc. 2023;145(30):16458-16463. PMCID: PMC10401710.

NIH Citation: Nachega JB, Scarsi KK, Gandhi M, Scott RK, Mofenson LM, Archary M, Nachman S, Decloedt E, Geng EH, Wilson L, Rawat A, Mellors JW. Long-acting antiretrovirals and HIV treatment adherence. Lancet HIV. 2023;10(5):e332-e342. PMCID: PMC10734401.

NIH Citation: Chidambaram S, Chang SH, Sandulache VC, Mazul AL, Zevallos JP. Human Papillomavirus Vaccination Prevalence and Disproportionate Cancer Burden Among US Veterans. JAMA Oncol. 2023;9(5):712-714. PMCID: PMC9982736.

NIH Citation: Paudel S, Warner BE, Wang R, Adams-Haduch J, Reznik AS, Dou J, Huang Y, Gao YT, Koh WP, Bäckerholm A, Yuan JM, Shair KHY. Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma. Clin Cancer Res. 2022;28(23):5221-5230. PMCID: PMC9722633.

NIH Citation: Wilson SR, Duncan AW. Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. Gastroenterology. 2022;162(1):46-48. PMCID: PMC8981166.

NIH Citation: Darrah KE, Deiters A. Translational control of gene function through optically regulated nucleic acids. Chem Soc Rev. 2021;50(23):13253-13267. PMCID: PMC8900068.

NIH Citation: Zhang T, Zhang SW, Zhang SY, Gao SJ, Chen Y, Huang Y. m6A-express: uncovering complex and condition-specific m6A regulation of gene expression. Nucleic Acids Res. 2021;49(20):e116. PMCID: PMC8599805.

NIH Citation: Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A. Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction. J Am Chem Soc. 2021;143(44):18665-18671. PMCID: PMC9014490.

NIH Citation: Mellors JW, Guo S, Naqvi A, Brandt LD, Su L, Sun Z, Joseph KW, Demirov D, Halvas EK, Butcher D, Scott B, Hamilton A, Heil M, Karim B, Wu X, Hughes SH. Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas. Sci Adv. 2021;7(42):eabi8795. PMCID: PMC8514100.

NIH Citation: Ryan A, Liu J, Deiters A. Targeted Protein Degradation through Fast Optogenetic Activation and Its Application to the Control of Cell Signaling. J Am Chem Soc. 2021;143(24):9222-9229.

NIH Citation: Zandberg DP, Menk AV, Velez M, Normolle D, DePeaux K, Liu A, Ferris RL, Delgoffe GM. Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck. J Immunother Cancer. 2021;9(5). PMCID: PMC8126285.

NIH Citation: Roth AN, Aravamudhan P, Fernández de Castro I, Tenorio R, Risco C, Dermody TS. Ins and Outs of Reovirus: Vesicular Trafficking in Viral Entry and Egress. Trends Microbiol. 2021;29(4):363-375. PMCID: PMC7523517.

NIH Citation: Li T, Wang X, Ju E, da Silva SR, Chen L, Zhang X, Wei S, Gao SJ. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Nat Commun. 2021;12(1):1055. PMCID: PMC7887217.

NIH Citation: Halvas EK, Joseph KW, Brandt LD, Guo S, Sobolewski MD, Jacobs JL, Tumiotto C, Bui JK, Cyktor JC, Keele BF, Morse GD, Bale MJ, Shao W, Kearney MF, Coffin JM, Rausch JW, Wu X, Hughes SH, Mellors JW. HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus. J Clin Invest. 2020;130(11):5847-5857. PMCID: PMC7598056.

NIH Citation: Bartlett DL. Better Biomarkers for Surgeons Treating Cancer. JAMA Surg. 2020;155(7):580.

NIH Citation: Kim E, Erdos G, Huang S, Kenniston TW, Balmert SC, Carey CD, Raj VS, Epperly MW, Klimstra WB, Haagmans BL, Korkmaz E, Falo LD Jr, Gambotto A. Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. EBioMedicine. 2020;55:102743. PMCID: PMC7128973.

NIH Citation: Lentscher AJ, McCarthy MK, May NA, Davenport BJ, Montgomery SA, Raghunathan K, McAllister N, Silva LA, Morrison TE, Dermody TS. Chikungunya virus replication in skeletal muscle cells is required for disease development. J Clin Invest. 2020;130(3):1466-1478. PMCID: PMC7269570.

NIH Citation: Ge Y, Wang H, Ren J, Liu W, Chen L, Chen H, Ye J, Dai E, Ma C, Ju S, Guo ZS, Liu Z, Bartlett DL. Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety. J Immunother Cancer. 2020;8(1). PMCID: PMC7103801.

NIH Citation: Naro Y, Darrah K, Deiters A. Optical Control of Small Molecule-Induced Protein Degradation. J Am Chem Soc. 2020;142(5):2193-2197. PMCID: PMC7229639.

NIH Citation: Ju E, Li T, Liu Z, da Silva SR, Wei S, Zhang X, Wang X, Gao SJ. Specific Inhibition of Viral MicroRNAs by Carbon Dots-Mediated Delivery of Locked Nucleic Acids for Therapy of Virus-Induced Cancer. ACS Nano. 2020;14(1):476-487. PMCID: PMC7119180.

NIH Citation: Courtney TM, Deiters A. Optical control of protein phosphatase function. Nat Commun. 2019;10(1):4384. PMCID: PMC6763421.

NIH Citation: Spudich S, Robertson KR, Bosch RJ, Gandhi RT, Cyktor JC, Mar H, Macatangay BJ, Lalama CM, Rinaldo C, Collier AC, Godfrey C, Eron JJ, McMahon D, Jacobs JL, Koontz D, Hogg E, Vecchio A, Mellors JW. Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance. J Clin Invest. 2019;129(8):3339-3346. PMCID: PMC6668666.

NIH Citation: Li T, Ju E, Gao SJ. Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis. J Clin Invest. 2019;129(8):3310-3323. PMCID: PMC6668677.

NIH Citation: Wilkinson PD, Delgado ER, Alencastro F, Leek MP, Roy N, Weirich MP, Stahl EC, Otero PA, Chen MI, Brown WK, Duncan AW. The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice. Hepatology. 2019;69(3):1242-1258. PMCID: PMC6532408.

NIH Citation: Ghosh A, Shao L, Sampath P, Zhao B, Patel NV, Zhu J, Behl B, Parise RA, Beumer JH, O'Sullivan RJ, DeLuca NA, Thorne SH, Rathinam VAK, Li P, Sarkar SN. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Immunity. 2019;50(1):51-63.e5. PMCID: PMC6342484.

NIH Citation: Guo ZS, Lu B, Guo Z, Giehl E, Feist M, Dai E, Liu W, Storkus WJ, He Y, Liu Z, Bartlett DL. Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics. J Immunother Cancer. 2019;7(1):6. PMCID: PMC6325819.

NIH Citation: Liu Z, Ge Y, Wang H, Ma C, Feist M, Ju S, Guo ZS, Bartlett DL. Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2. Nat Commun. 2018;9(1):4682. PMCID: PMC6224581.