Journal: Nucleic Acids Res
Publication Date: 2025-08-27
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Journal: J Immunother Cancer
Publication Date: 2025-08-25
DOI: 10.1136/jitc-2025-012053
NIH Citation: Sobti A, Mowery YM. Priming the tumor microenvironment with pembrolizumab and radiotherapy for durable cures in high-risk localized undifferentiated pleomorphic sarcoma and pleomorphic/dedifferentiated liposarcoma. J Immunother Cancer. 2025;13(8). PMCID: PMC12382580.
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Journal: Nat Microbiol
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NIH Citation: Liu J, Zuo Z, Ewing M, Cao Q, Cao L, Li Q, Finkel T, Leppla SH, Liu S. ERK pathway reactivation prevents anthrax toxin lethality in mice. Nat Microbiol. 2025;.
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Journal: J Clin Invest
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NIH Citation: Xu J, Du W. HoxBlinc: a key driver of chromatin dynamics in NUP98 fusion-driven leukemia. J Clin Invest. 2025;135(7). PMCID: PMC11957688.
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Journal: Hepatology
Publication Date: 2025-02-01
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NIH Citation: Duncan AW. Pathological polyploidy and liver repair failure in RAD51-deficient mice. Hepatology. 2025;. PMCID: PMC12036278.
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Journal: Nat Commun
Publication Date: 2025-01-21
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NIH Citation: De Rosa M, Barnes RP, Detwiler AC, Nyalapatla PR, Wipf P, Opresko PL. OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts. Nat Commun. 2025;16(1):893. PMCID: PMC11751180.
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Journal: Mol Cell
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NIH Citation: Kuper J, Kisker C, Van Houten B. Unlocking transcription-coupled DNA repair with the STK19 key. Mol Cell. 2024;84(24):4693-4695.
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Journal: Lancet
Publication Date: 2024-11-23
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Journal: Nat Commun
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NIH Citation: Schnable BL, Schaich MA, Roginskaya V, Leary LP, Weaver TM, Freudenthal BD, Drohat AC, Van Houten B. Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine. Nat Commun. 2024;15(1):9226. PMCID: PMC11512004.
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Journal: Clin Cancer Res
Publication Date: 2024-09-13
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NIH Citation: Mowery YM, Luke JJ. NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance. Clin Cancer Res. 2024;. PMCID: PMC11398986.
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Journal: Nat Commun
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NIH Citation: Hinchie AM, Sanford SL, Loughridge KE, Sutton RM, Parikh AH, Gil Silva AA, Sullivan DI, Chun-On P, Morrell MR, McDyer JF, Opresko PL, Alder JK. A persistent variant telomere sequence in a human pedigree. Nat Commun. 2024;15(1):4681. PMCID: PMC11144197.
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Journal: Nat Struct Mol Biol
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Journal: Nat Commun
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NIH Citation: Muoio D, Laspata N, Dannenberg RL, Curry C, Darkoa-Larbi S, Hedglin M, Uttam S, Fouquerel E. PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress. Nat Commun. 2024;15(1):2857. PMCID: PMC10987537.
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Journal: Nucleic Acids Res
Publication Date: 2024-02-28
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NIH Citation: Johnson SA, Paul T, Sanford SL, Schnable BL, Detwiler AC, Thosar SA, Van Houten B, Myong S, Opresko PL. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024;. PMCID: PMC10939409.
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Journal: Clin Cancer Res
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Journal: Blood
Publication Date: 2023-11-02
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NIH Citation: Wu L, Lin Q, Chatla S, Amarachintha SP, Wilson AF, Atale N, Gao ZJ, Joseph J, Wolff E, Du W. LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging. Blood. 2023;. PMCID: PMC10656728.
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Journal: Redox Biol
Publication Date: 2023-10-01
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NIH Citation: Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. Redox Biol. 2023;66:102856. PMCID: PMC10472314.
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Journal: Trends Genet
Publication Date: 2023-08-01
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Journal: Nucleic Acids Res
Publication Date: 2023-06-09
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NIH Citation: Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023;51(10):4881-4898. PMCID: PMC10250209.
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Journal: Nucleic Acids Res
Publication Date: 2023-06-09
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NIH Citation: Ellison MA, Namjilsuren S, Shirra MK, Blacksmith MS, Schusteff RA, Kerr EM, Fang F, Xiang Y, Shi Y, Arndt KM. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2023;51(10):4814-4830. PMCID: PMC10250246.
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Journal: Redox Biol
Publication Date: 2023-05-01
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NIH Citation: Tyurina YY, Kapralov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023;61:102650. PMCID: PMC9996109.
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Journal: Nucleic Acids Res
Publication Date: 2023-04-24
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NIH Citation: Schaich MA, Schnable BL, Kumar N, Roginskaya V, Jakielski RC, Urban R, Zhong Z, Kad NM, Van Houten B. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023;51(7):e39. PMCID: PMC10123111.
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Journal: Nucleic Acids Res
Publication Date: 2023-03-21
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NIH Citation: Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023;51(5):2215-2237. PMCID: PMC10018367.
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Journal: Nucleic Acids Res
Publication Date: 2022-12-09
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NIH Citation: Jang S, Kumar N, Schaich MA, Zhong Z, van Loon B, Watkins SC, Van Houten B. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022;50(22):12856-12871. PMCID: PMC9825174.
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Journal: Science
Publication Date: 2022-11-11
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NIH Citation: Chun-On P, Hinchie AM, Beale HC, Gil Silva AA, Rush E, Sander C, Connelly CJ, Seynnaeve BKN, Kirkwood JM, Vaske OM, Greider CW, Alder JK. TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science. 2022;378(6620):664-668. PMCID: PMC10590476.
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Journal: Mol Cell
Publication Date: 2022-11-03
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Journal: Redox Biol
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NIH Citation: Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022;56:102443. PMCID: PMC9450138.
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Journal: Physiol Rev
Publication Date: 2022-10-01
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NIH Citation: Alder JK, Armanios M. Telomere-mediated lung disease. Physiol Rev. 2022;102(4):1703-1720. PMCID: PMC9306791.
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Journal: Nat Struct Mol Biol
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Journal: J Clin Invest
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NIH Citation: Lin Q, Wu L, Chatla S, Chowdhury FA, Atale N, Joseph J, Du W. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest. 2022;132(12). PMCID: PMC9197516.
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Journal: Cancer Res
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NIH Citation: Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022;82(7):1340-1352. PMCID: PMC8983601.
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Journal: Redox Biol
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NIH Citation: Ruan H, Leibowitz BJ, Peng Y, Shen L, Chen L, Kuang C, Schoen RE, Lu X, Zhang L, Yu J. Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer. Mol Biomed. 2022;3(1):10. PMCID: PMC8934835.
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Journal: Sci Adv
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Journal: Cancer Res
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Journal: Nat Commun
Publication Date: 2022-02-21
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Journal: Sci Adv
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Journal: Gastroenterology
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NIH Citation: Wilson SR, Duncan AW. Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. Gastroenterology. 2022;162(1):46-48. PMCID: PMC8981166.
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Journal: Nucleic Acids Res
Publication Date: 2021-12-16
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Journal: Redox Biol
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Journal: Trends Biochem Sci
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Journal: Cell
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NIH Citation: Xu J, Ma H, Ma H, Jiang W, Mela CA, Duan M, Zhao S, Gao C, Hahm ER, Lardo SM, Troy K, Sun M, Pai R, Stolz DB, Zhang L, Singh S, Brand RE, Hartman DJ, Hu J, Hainer SJ, Liu Y. Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis. Nat Commun. 2020;11(1):1899. PMCID: PMC7171144.
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Journal: Nat Commun
Publication Date: 2020-03-13
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NIH Citation: Beckwitt EC, Jang S, Carnaval Detweiler I, Kuper J, Sauer F, Simon N, Bretzler J, Watkins SC, Carell T, Kisker C, Van Houten B. Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search. Nat Commun. 2020;11(1):1356. PMCID: PMC7069974.
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Journal: Trends Cancer
Publication Date: 2020-03-01
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NIH Citation: Hoang SM, O'Sullivan RJ. Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends. Trends Cancer. 2020;6(3):247-260. PMCID: PMC7199893.
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Journal: Nat Chem Biol
Publication Date: 2020-03-01
DOI: 10.1038/s41589-019-0462-8
NIH Citation: Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayır H, Kagan VE. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16(3):278-290. PMCID: PMC7233108.
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Journal: Nat Cell Biol
Publication Date: 2020-03-01
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NIH Citation: Betegon M, Brodsky JL. Unlocking the door for ERAD. Nat Cell Biol. 2020;22(3):263-265. PMCID: PMC7199279.
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Journal: Nucleic Acids Res
Publication Date: 2019-11-04
DOI: 10.1093/nar/gkz738
NIH Citation: Martino J, Brunette GJ, Barroso-González J, Moiseeva TN, Smith CM, Bakkenist CJ, O'Sullivan RJ, Bernstein KA. The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination. Nucleic Acids Res. 2019;47(19):10151-10165. PMCID: PMC6821187.
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Journal: Mol Cell
Publication Date: 2019-10-03
DOI: 10.1016/j.molcel.2019.06.043
NIH Citation: Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019;76(1):11-26.e7. PMCID: PMC6778027.
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Journal: Nucleic Acids Res
Publication Date: 2019-09-19
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NIH Citation: Cucinotta CE, Hildreth AE, McShane BM, Shirra MK, Arndt KM. The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo. Nucleic Acids Res. 2019;47(16):8410-8423. PMCID: PMC6895269.
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Journal: Nat Commun
Publication Date: 2019-08-05
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NIH Citation: Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA. The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. Nat Commun. 2019;10(1):3515. PMCID: PMC6683157.
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Journal: Nat Struct Mol Biol
Publication Date: 2019-08-01
DOI: 10.1038/s41594-019-0261-7
NIH Citation: Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 2019;26(8):695-703. PMCID: PMC6684372.
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Journal: Mol Cell
Publication Date: 2019-07-11
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NIH Citation: Fouquerel E, Barnes RP, Uttam S, Watkins SC, Bruchez MP, Opresko PL. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol Cell. 2019;75(1):117-130.e6. PMCID: PMC6625854.
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Journal: Nat Cell Biol
Publication Date: 2019-06-01
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NIH Citation: Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR 3rd, Ren B, Cleveland DW. DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres. Nat Cell Biol. 2019;21(6):743-754. PMCID: PMC7015266.
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Journal: Hepatology
Publication Date: 2019-05-01
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NIH Citation: Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019;69(5):2164-2179. PMCID: PMC6461480.
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Journal: Sci Adv
Publication Date: 2019-04-01
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Journal: Cancer Res
Publication Date: 2019-03-15
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Journal: Hepatology
Publication Date: 2019-03-01
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NIH Citation: Wilkinson PD, Delgado ER, Alencastro F, Leek MP, Roy N, Weirich MP, Stahl EC, Otero PA, Chen MI, Brown WK, Duncan AW. The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice. Hepatology. 2019;69(3):1242-1258. PMCID: PMC6532408.
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Journal: Clin Cancer Res
Publication Date: 2019-03-01
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NIH Citation: Clump DA, Pickering CR, Skinner HD. Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects. Clin Cancer Res. 2019;25(5):1441-1442. PMCID: PMC6415532.
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Journal: Redox Biol
Publication Date: 2019-02-01
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NIH Citation: Hopkins BL, Neumann CA. Redoxins as gatekeepers of the transcriptional oxidative stress response. Redox Biol. 2019;21:101104. PMCID: PMC6351230.
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Journal: JAMA Oncol
Publication Date: 2019-02-01
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NIH Citation: Steward DL, Carty SE, Sippel RS, Yang SP, Sosa JA, Sipos JA, Figge JJ, Mandel S, Haugen BR, Burman KD, Baloch ZW, Lloyd RV, Seethala RR, Gooding WE, Chiosea SI, Gomes-Lima C, Ferris RL, Folek JM, Khawaja RA, Kundra P, Loh KS, Marshall CB, Mayson S, McCoy KL, Nga ME, Ngiam KY, Nikiforova MN, Poehls JL, Ringel MD, Yang H, Yip L, Nikiforov YE. Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study. JAMA Oncol. 2019;5(2):204-212. PMCID: PMC6439562.
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Journal: J Am Chem Soc
Publication Date: 2018-12-26
DOI: 10.1021/jacs.8b09913
NIH Citation: Anthonymuthu TS, Kenny EM, Shrivastava I, Tyurina YY, Hier ZE, Ting HC, Dar HH, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Zhao J, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayır H. Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE. J Am Chem Soc. 2018;140(51):17835-17839. PMCID: PMC6622169.
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