Sandra Cascio

Summary

My laboratory investigates the intercellular communications between stroma, tumor cells and immune cells within the tumor microenvironment. I am particularly focused on gaining a better understanding of how factors, secreted by stromal and tumor cells, modulate the immunosuppressive activities of tumor-associated myeloid cells, driving resistance to immunotherapies. Using mouse models of ovarian cancer and clinical samples, my long-term goal is to identify novel therapeutical approaches to enhance anti-tumor immunity.