Kazunori Koide

Summary

We are currently studying FR901464, a natural product that regulates cancer-related genes by modulating splicing factor 3B subunit 1 (SF3B1) and PHF5A. This compound inhibits cancer proliferation at concentrations as low as 1 nM. To study FR901464, we completed a chemical total synthesis of this natural product. Our synthetic analogs of FR901464, meayamycins, inhibit tumor growth at 10 pM. Additionally, we develop fluorescent probes to gain spatiotemporal insights into hydrogen peroxide, copper ions, and platinum drugs.