Investigators

Summary

The Cillo Lab focuses on understanding how immune cells make cell fate decisions, how intercellular communication influences these cell fate decisions, and the ways in which cell-cell interactions shape community dynamics in the tumor microenvironment. To address these questions, we are utilizing high-dimensional systems based approaches including spectral flow cytomtery, single-cell RNAseq and spatial transcriptomics in the context of patients with solid tumors such as head and neck cancer, sarcoma, and melanoma among others. Defining the contributions of individual immune populations and their behavior in aggregate will allow us to understand how current immunotherapies promote antitumor immunity and why current immunotherapies fail in some patients. Additionally, it will enable us to identify new therapeutic targets to promote antitumor immunity in a larger proportion of patients with solid tumors.