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Dennis Hsu

Dennis Hsu

Program: Cancer Biology

(412) 623-1722 Hillman Cancer Center Research Pavilion
5117 Centre Avenue, Lab 1.20
Pittsburgh PA

I am a physician-scientist whose research efforts have focused specifically on codon usage, tRNA biology, and amino acid metabolism in colorectal and gastric cancers. Using a combination of computational modeling and wet-lab experiments, I found that amino acid availability directly influences tRNA availability and gene expression in a codon-dependent manner, and also potentially affects the evolution of the cancer genome. I plan to better dissect the contribution of the tumor microenvironment towards nutritional stress of cancer cells as well as determine how tRNA synthetases contribute to survival under starvation conditions.

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