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Karen Arndt

Karen Arndt

Program: Genome Stability

412-624-6963 arndt@pitt.edu A316 Langley Hall
4249 Fifth Ave
Pittsburgh PA
Summary

A critical question to ask, particularly in this genomic era, is how organisms interpret the vast amounts of information encoded in their genomes. The Arndt lab studies the first step in gene expression, the synthesis of mRNA by RNA polymerase II, with a focus on the mechanisms that regulate transcription in the chromatin environment of a eukaryotic cell. The fundamental importance of understanding transcriptional regulation is evident from the large number of human developmental defects and diseases, including cancer and AIDS, that arise when cellular transcription factors are altered by mutation or commandeered by viral proteins.

Research Interests and Keywords
  • Gene expression
  • cellular transcription
  • mRNA synthesis
  • RNA polymerase II
  • chromatin
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