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Lawrence Kane

Lawrence Kane

Program: Cancer Immunology and Immunotherapy

412-383-6880 lkane@pitt.edu E-1054 BSTWR
200 Lothrop St.
Pittsburgh PA
Summary

My lab is focused on the study of signal transduction pathways that regulate antigen-dependent activation of T cells and mast cells. Toward that end, we are engaged in several specific projects: 1. Understanding the signaling pathways downstream of Carma1, MALT1 and Bcl10 (CBM complex) in T cells 2. Defining biochemical and spatial regulation of NF-kB activation by the TCR/CD3 complex, along with CD28 co-stimulation 3. Understanding signal transduction pathways downstream of the transmembrane proteins Tim-1 and Tim-3, in T cells and mast cells

Research Interests and Keywords
  • T cells
  • signal transduction
  • kinases
  • immunology
  • mast cells
  • co-stimulation
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