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Roderick O'Sullivan

Roderick O'Sullivan

Program: Genome Stability Hillman Cancer Center
5117 Centre Avenue Suite 2.6d
Pittsburgh PA

The O’Sullivan lab at UPMC Hillman Cancer Center conducts research into proteins that alter the structural and epigenetic functions of human telomeres. Telomeres are structures at the ends of chromosomes – the integrity of telomeres is an important factor in maintaining genome stability to prevent cancer and accelerated aging. Current efforts in the lab relate to: (i) deciphering the relationship between the regulation between chromatin structure and telomere function and (ii) new aspects of ADP-ribosylation in genome stability.

Research Interests and Keywords
  • ADP-ribosylation
  • Cancer
  • DNA Damage
  • Epigenetics
  • Telomere
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