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Satdarshan Monga

Satdarshan Monga

Program: Cancer Biology

smonga@pitt.edu S400 BST South
200 Lothrop Street
Pittsburgh PA
Summary

Dr. Monga's laboratory is focused on understanding the molecular mechanisms of liver growth and development in health and disease, especially in the context of regeneration and cancer. Several signaling pathways have been identified to direct such events, including the Wnt/beta-catenin, HGF/Met, and PDGFR pathways.

Liver development in mice is initiated at around E8-8.5 stages of gestational development. Once foregut endoderm gains competence hepatic signatures are initiated during the process of which undergo expansion and regulated differentiation into hepatocytes and biliary epithelial cells during the process of morphogenesis. One of the major focuses of the Monga laboratory is to identify the molecular basis of hepatic morphogenesis. More specificallyinduction. The primitive liver bud contains bipotential stem cells or progenitors how does the hepatic progenitor or the bipotential stem cell undergo self-renewal (symmetric division) lineage specification and differentiate further towards primitive bile duct cells or immature hepatocytes (asymmetric division) and then to fully differentiated cells? Using conditional null mice embryonic liver cultures and other modalities the lab is investigating the roles regulation and interactions of various pathways which will not only further our understanding of this fundamental biological process but might also provide insight into the molecular basis of disease that recapitulates development in adulthood hepatocellular cancer (HCC). HCC is the third leading cause of cancer death and remains a disease with poor treatment options. Targeting pathways that are normally upregulated during liver development at the time of peak proliferation and stem cell renewal represents a novel therapeutic measure for the treatment of HCC."

Research Interests and Keywords
  • EGF
  • growth factors
  • hepatic physiology
  • Hepatocellular carcinoma
  • HGF/Met
  • Liver cancer
  • liver development
  • liver disease
  • PDGF
  • Signal Transduction
  • Wnt/beta-catenin
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