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Saul Shiffman

Saul Shiffman

Program: Biobehavioral Cancer Control

412-383-2051 510 BELPB
130 N. Bellefield Avenue
Pittsburgh PA

Dr. Shiffman's research focuses on tobacco use and nicotine dependence and their development, the nicotine withdrawal syndrome, smoking relapse, behavioral and pharmacological treatment for smoking, and tobacco control. Dr. Shiffman is currently conducting two trials, both focused on non-daily smokers, who are a substantial and growing fraction of adult smokers. The first study focuses on assessing the effects of switching to very low nicotine content cigarettes (VLNCCs) among intermittent smokers (ITS). This is a two-arm randomized study with an own-cigarette baseline control. After a 2-week baseline period smoking their own cigarettes, ITS will be randomized for 10 weeks to smoke experimental cigarettes, either (a) normal nicotine content cigarettes, or VLNCCs. Change in cigarette consumption is the primary end-point, and biomarkers of smoke exposure and measures of smoking intensity are also assessed. The second study focuses on the effect of as-needed oral Nicotine Replacement Therapy (NRT) for smoking cessation in ITS, and to study the process of relapse in ITS, using Ecological Momentary Assessment (EMA). Reviews of ITS have called for research on ITS' relapse process, and for evaluation of cessation methods, including medications, among ITS. This will be a double-blind, randomized, placebo-controlled trial of oral NRT for smoking cessation in ITS. EMA data collection includes two weeks of baseline data on ad lib smoking patterns and 6 weeks of post-quit data, using methods we successfully fielded in our previous research. This will capture data on craving, withdrawal, and relapse among ITS, and relate relapse contexts to baseline smoking patterns.

Research Interests and Keywords
  • dependence
  • Smoking
  • Smoking Cessation
  • Tobacco
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