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Cancer Prevention investigators

Wendie Berg
Jane Cauley, DrPH
Contact:
130 De Soto Street, A533 Crabtree Hall
Pittsburgh PA
Research Interests and Keywords:
  • Breast cancer
  • epidemiology
  • sex hormones
  • osteoporosis
Summary
Dr. Cauley's primary research interest is the epidemiology of osteoporosis, osteoporosis treatment and the consequences of osteoporosis in both men and women. She also has a major interest in breast cancer and served on the American Society of Clinical Oncology Writing Group about the use of bisphosphonates in women with breast cancer. Her other research has focused on women's health and aging, falls, the interaction between endogenous and exogenous hormones, risk factors, inflammation, and disease outcomes. She examines the physical and psychological changes that occur in postmenopausal women.
James Herman, MD
Contact:
Hillman Cancer Center, 2.18d
Pittsburgh PA
Research Interests and Keywords:
  • Lung cancer
  • DNA methylation
  • tumor suppressor genes
  • epigenetics
  • biomarkers
  • transcription factors
  • early detection
  • cancer prognosis
Rachel Jankowitz, MD
Contact:
UPMC CancerCenter at Magee-Womens Hospital of UPMC
300 halket Street
Pittsburgh PA
Research Interests and Keywords:
  • Breast cancer
  • medical oncology
Luis Ortiz, MD
Contact:
Bridgeside Point, 100 Technology Drive
Room 557, BRIDG
Pittsburgh PA
Phone: 412-624-5269
Research Interests and Keywords:
  • Lung cancer
  • lung injury
  • fibrotic lung disease
  • pulmonary fibrosis
  • mesenchymal stem cells (MSCs)
Summary
Dr. Ortiz focuses his research on mechanisms that mediate the development of lung injury including those leading to the development of fibrotic lung disease. In particular, his laboratory has contributed to this field with the development of mouse models of pulmonary fibrosis (silica and bleomycin) and most recently with the concept that bone marrow derived mesenchymal stem cells (MSCs) are fundamental contributors to the repair of the injured lung.
Robert Schoen, MD, MPH
Contact:
PUH - Mezz. 2 - C Wing
200 Lothrop Street
Pittsburgh PA
Research Interests and Keywords:
  • Early detection and prevention of colorectal cancer (CRC)
  • flexible sigmoidoscopy
  • acceptability and implementation of CRC screening
  • surveillance colonoscopy
  • relationship of insulin/insulin-like growth factors to adenomatous polyps and CRC
David Whitcomb, MD, PhD
Contact:
Mezzanine Level
C-Wing-PUH 200 Lothrop Street
Pittsburgh PA
Research Interests and Keywords:
  • Mechanisms of complex disorders including acute pancreatitis, chronic pancreatitis, and pancreatic cancer
Linwah Yip, MD
Contact:
Kaufmann Building
3471 Fifth Ave, Suite 101
Pittsburgh PA
Phone: 412-647-0467
Research Interests and Keywords:
  • Thyroid cancer
  • parathyroid cancer
  • molecular markers
  • biomarkers
Summary
Dr. Yip's primary research interest is evaluating the role of molecular markers in thyroid and parathyroid cancer to improve risk stratification and optimize efficacy in patient management algorithms.
Randall Brand, MD
Contact:
Shadyside Medical Building
5200 Centre Avenue, Suite 409
Pittsburgh PA
Research Interests and Keywords:
  • Hereditary pancreatic cancer
  • early detection of pancreatic cancer
  • pancreatitis
  • colon cancer
Laura Korb Ferris, MD, PhD
Contact:
3708 Fifth Avenue
Fifth Floor, Suite 500.68
Pittsburgh PA
Phone: 412-647-4200
Research Interests and Keywords:
  • Melanoma
  • dermatoscope
  • early detection
  • screening
Summary
Melanoma is a deadly cancer when caught late yet is a surgically curable disease when detected and treated at the earliest stages. Fortunately, most melanomas begin on the skin, and thus we have the opportunity to detect them using visual examination. However, early detection of melanoma can be challenging even for the most experienced dermatologists. This can lead to failure to detect melanoma when it is most treatable or to a high rate of removal of benign lesions. Both increase health care costs and put patients at risk. My research focuses on new techniques to improve the early detection of cutaneous melanoma. Computer vision technology can be applied to the analysis of specialized images of pigmented skin lesions taken using a handheld instrument called a dermatoscope. We are studying ways to use the objective, analytical power of the computer to take a dermatoscopic image of a pigmented skin lesion and rapidly quantify features such as symmetry, size, and color distribution. The system can then compare a lesion that has not been biopsied to a database of images from lesions for which a diagnosis has been made using histopathology following removal (the gold standard for diagnosis of melanoma and other skin lesions) to aid the user in making a decision of whether or not to biopsy. In addition, I am interested in understanding which patients benefit most from screening for melanoma and have several publications that examine melanoma epidemiology, detection patterns, and associations between melanoma screening and outcomes.
Jing Hu, MD, PhD
Contact:
5117 Centre Avenue, Suite 2.32B
Pittsburgh PA
Research Interests and Keywords:
  • Protein kinases and phosphatases
  • post-translational modifications
  • sumoylation
  • histone deacetylases
  • cancer biology
Stephen O'Keefe
Jiantao Pu
Shivendra Singh, PhD
Contact:
2.32A Hillman Cancer Research Pavilion
5117 Centre Ave
Pittsburgh PA
Phone: 412-623-3262
Research Interests and Keywords:
  • Cancer pharmacology
  • drug discovery
  • chemoprevention
  • dietary anti-cancer compounds
  • isothiocynates
  • organosulides
  • withaferin A
  • cancer prevention
Summary
The primary research interests of the Singh laboratory include molecular characterization of novel cancer chemopreventive agents and rational design of mechanism-driven combination chemoprevention regimens. Cellular and transgenic animal models are used to screen potential cancer chemopreventive constituents from dietary and medicinal plants. Cutting edge cellular, molecular biological, omics (metabolomics and proteomics), structural biology, and imaging techniques (MRI and bioluminescence) are used to (a) determine the mechanism of action of promising cancer chemopreventive agents, (b) monitor effects on cancer progression, and (c) identify biomarkers predictive of tissue exposure and possibly response. Some of the agents under active investigation in the Singh laboratory include: cruciferous vegetable-derived isothiocyanates, garlic-derived organosulides, and medicinal plant constituent withaferin A. As an example, recent published work from the Singh laboratory indicates suppression of glycolysis in mammary cancer prevention by withaferin A in a transgenic mouse model. Likewise, complementary cellular and molecular biological, targeted proteomics, and molecular modeling techniques were used to identify beta-tubulin as a novel target of cancer cell growth arrest by withaferin A (WA).
David Wilson, MD, MPH
Contact:
5150 Centre Ave. Ste. 4c
Pittsburgh PA
Phone: 412-687-3355
Research Interests and Keywords:
  • Lung cancer screening, chemoprevention, diagnosis, staging and treatment
  • COPD
  • pulmonary medicine
Summary
Dr. Wilson's research interests include: lung cancer screening and chemoprevention, diagnosis, staging and treatment; COPD, especially as it relates to lung cancer; occupational lung diseases; and general pulmonary medicine.
Jian-Min Yuan, MD, PhD
Contact:
UPMC Cancer Pavilion
5150 Centre Avenue - Suite 4C Office 470
Pittsburgh PA
Phone: 412-864-7889
Research Interests and Keywords:
  • Gene-environment interaction in cancer etiology
  • cancer biomarkers
  • cancer risk prediction
  • dietary chemopreventive agents
  • cancer epidemiology
  • cancer prevention
  • clinical trials
Summary
Dr. Yuan is a cancer epidemiologist with extensive experience in research on cancer etiology and prevention. Dr. Yuan is Principal Investigator of the Shanghai Cohort Study and the Singapore Chinese Health Study, two population-based prospective cohorts of more than 80,000 Chinese men and women with available baseline blood and urine samples with more than 25 years of active follow-up for cancer and other major health outcomes.

Utilizing these two large cohort resources coupled with a biomarker approach, Dr. Yuan and his research team have made several noteworthy contributions to the field of cancer epidemiology including (1) dietary aflatoxins as human hepatocarcinogens, (2) dietary isothiocyanates, a group of phytochemicals found in cruciferous vegetables, as potential chemopreventive agents against lung cancer development, and (3) urinary biomarkers of nicotine, tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons as risk predictors for lung cancer in smokers.

Dr. Yuan also has extensive experience in designing and conducting randomized, double-blind intervention studies on cancer prevention. Dr. Yuan is leading the effort to conduct a randomized, double-blind phase II clinical trial to evaluate the effectiveness of dietary 2-phenethyl isothiocyanates (PEITC) supplementation on reduction of risk markers for lung cancer in smokers. In addition, Dr. Yuan, collaborating with Dr. Mindy Kurzer, his former colleague at the University of Minnesota, is conducting a randomized, double-blind phase II clinical trial to evaluate the efficacy of oral supplementation of green tea extracts (Polyphenon E) on reduction of risk markers for breast cancer in women.

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