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Cancer Prevention investigators

Randall Brand, MD
Shadyside Medical Building
5200 Centre Avenue, Suite 409
Pittsburgh PA
Research Interests and Keywords:
  • Hereditary pancreatic cancer
  • early detection of pancreatic cancer
  • pancreatitis
  • colon cancer
James Herman, MD
Hillman Cancer Center, 2.18d
Pittsburgh PA
Research Interests and Keywords:
  • Lung cancer
  • DNA methylation
  • tumor suppressor genes
  • epigenetics
  • biomarkers
  • transcription factors
  • early detection
  • cancer prognosis
Hung Luu, MD, PhD
Robert Schoen, MD, MPH
PUH - Mezz. 2 - C Wing
200 Lothrop Street
Pittsburgh PA
Research Interests and Keywords:
  • Early detection and prevention of colorectal cancer (CRC)
  • flexible sigmoidoscopy
  • acceptability and implementation of CRC screening
  • surveillance colonoscopy
  • relationship of insulin/insulin-like growth factors to adenomatous polyps and CRC
David Whitcomb, MD, PhD
Mezzanine Level
C-Wing-PUH 200 Lothrop Street
Pittsburgh PA
Research Interests and Keywords:
  • Mechanisms of complex disorders including acute pancreatitis, chronic pancreatitis, and pancreatic cancer
Linwah Yip, MD
Kaufmann Building
3471 Fifth Ave, Suite 101
Pittsburgh PA
Phone: 412-647-0467
Research Interests and Keywords:
  • Thyroid cancer
  • parathyroid cancer
  • molecular markers
  • biomarkers
Dr. Yip's primary research interest is evaluating the role of molecular markers in thyroid and parathyroid cancer to improve risk stratification and optimize efficacy in patient management algorithms.
Joseph Zmuda, PhD
A544 Crabtree Hall
Pittsburgh PA
Phone: 412-624-2970
Research Interests and Keywords:
  • Genetic and molecular epidemiology
  • osteoporosis
  • aging
My research primarily focuses on the epidemiology and genetics of osteoporosis. A long-term goal is to identify and characterize the genetic factors underlying osteoporosis susceptibility in different ethnic/racial groups. To achieve these goals, we have used several strategies including: population-based candidate gene methods; genome-wide admixture, linkage and association mapping; and most recently, an in vitro cellular model. This later approach is enabling us to translate discoveries made at the cellular level to the 'population' and vice versa to gain insight into the molecular genetic mechanisms underlying osteoporosis susceptibility.
Brenda Diergaarde, PhD
UPMC Cancer Pavilion
5150 Centre Ave, Suite 4C
Pittsburgh PA
Phone: 412-623-5891
Research Interests and Keywords:
  • Molecular epidemiology
  • cancer epidemiology
  • genetic variation
  • diet
  • lifestyle
  • cancer prevention
  • biomarkers
  • lung cancer
  • head and neck cancer

Dr. Diergaarde's research examines the role of diet, lifestyle and genetic variation in the development, progression and treatment of cancer, including cancers of the lung, head and neck, colon, ovaries and breast, and aims to identify markers for risk stratification, early detection and response to treatment. She is currently Co-Leader of Project 2 of the UPCI Specialized Program of Research Excellence (SPORE) in Lung Cancer. This project seeks to establish the relationship between vitamin D exposure, pulmonary inflammation and lung cancer risk and so provide strong rationale for a vitamin D-based approach to lung cancer prevention. She is also Leader of Project 1 of the UPCI SPORE in Head and Neck Cancer. Using data and samples from a large, clinic-based case-control study, this project investigates the role of genetic variation and gene-environment interactions in the development, progression and treatment of head and neck squamous cell carcinoma.

Francesmary Modugno, PhD, MPH
Shivendra Singh, PhD
2.32A Hillman Cancer Research Pavilion
5117 Centre Ave
Pittsburgh PA
Phone: 412-623-3262
Research Interests and Keywords:
  • Cancer pharmacology
  • drug discovery
  • chemoprevention
  • dietary anti-cancer compounds
  • isothiocynates
  • organosulides
  • withaferin A
  • cancer prevention

The primary research interests of the Singh laboratory include molecular characterization of novel cancer chemopreventive agents and rational design of mechanism-driven combination chemoprevention regimens. Cellular and transgenic animal models are used to screen potential cancer chemopreventive constituents from dietary and medicinal plants. Cutting edge cellular, molecular biological, omics (metabolomics and proteomics), structural biology, and imaging techniques (MRI and bioluminescence) are used to (a) determine the mechanism of action of promising cancer chemopreventive agents, (b) monitor effects on cancer progression, and (c) identify biomarkers predictive of tissue exposure and possibly response. Some of the agents under active investigation in the Singh laboratory include: cruciferous vegetable-derived isothiocyanates, garlic-derived organosulides, and medicinal plant constituent withaferin A. As an example, recent published work from the Singh laboratory indicates suppression of glycolysis in mammary cancer prevention by withaferin A in a transgenic mouse model. Likewise, complementary cellular and molecular biological, targeted proteomics, and molecular modeling techniques were used to identify beta-tubulin as a novel target of cancer cell growth arrest by withaferin A (WA).

David Wilson, MD, MPH
5150 Centre Ave. Ste. 4c
Pittsburgh PA
Phone: 412-687-3355
Research Interests and Keywords:
  • Lung cancer screening, chemoprevention, diagnosis, staging and treatment
  • COPD
  • pulmonary medicine

Dr. Wilson's research interests include: lung cancer screening and chemoprevention, diagnosis, staging and treatment; COPD, especially as it relates to lung cancer; occupational lung diseases; and general pulmonary medicine.

Jian-Min Yuan, MD, PhD
UPMC Cancer Pavilion
5150 Centre Avenue - Suite 4C Office 470
Pittsburgh PA
Phone: 412-864-7889
Research Interests and Keywords:
  • Gene-environment interaction in cancer etiology
  • cancer biomarkers
  • cancer risk prediction
  • dietary chemopreventive agents
  • cancer epidemiology
  • cancer prevention
  • clinical trials

Dr. Yuan is a cancer epidemiologist with extensive experience in research on cancer etiology and prevention. Dr. Yuan is Principal Investigator of the Shanghai Cohort Study and the Singapore Chinese Health Study, two population-based prospective cohorts of more than 80,000 Chinese men and women with available baseline blood and urine samples with more than 25 years of active follow-up for cancer and other major health outcomes.

Utilizing these two large cohort resources coupled with a biomarker approach, Dr. Yuan and his research team have made several noteworthy contributions to the field of cancer epidemiology including (1) dietary aflatoxins as human hepatocarcinogens, (2) dietary isothiocyanates, a group of phytochemicals found in cruciferous vegetables, as potential chemopreventive agents against lung cancer development, and (3) urinary biomarkers of nicotine, tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons as risk predictors for lung cancer in smokers.


Dr. Yuan also has extensive experience in designing and conducting randomized, double-blind intervention studies on cancer prevention. Dr. Yuan is leading the effort to conduct a randomized, double-blind phase II clinical trial to evaluate the effectiveness of dietary 2-phenethyl isothiocyanates (PEITC) supplementation on reduction of risk markers for lung cancer in smokers. In addition, Dr. Yuan, collaborating with Dr. Mindy Kurzer, his former colleague at the University of Minnesota, is conducting a randomized, double-blind phase II clinical trial to evaluate the efficacy of oral supplementation of green tea extracts (Polyphenon E) on reduction of risk markers for breast cancer in women.