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Conduct Early-Phase (I/II) Clinical Trials investigators

Leonard Appleman, MD, PhD
Contact:
UPMC Cancer Pavilion
5230 Center Ave., Suite 567
Pittsburgh PA
Phone: 412-648-6507
Research Interests and Keywords:
  • Kidney cancer and other genitourinary malignancies
  • experimental cancer therapeutics
Jan-Hendrik Beumer, PharmD, PhD
Contact:
G27E Hillman Cancer Center
5117 Centre Avenue
Pittsburgh PA
Phone: 412-623-3216
Research Interests and Keywords:
  • Pharmacokinetics and metabolism of anti-cancer drugs
  • nucleoside analogues and epigenetic drugs
Adam Brufsky, MD, PhD
Contact:
300 Halket St
Suite 4628
Pittsburgh PA
Research Interests and Keywords:
  • Breast cancer
  • clinical trials
  • molecular biology of breast cancer
Melissa Burgess, MD
Contact:
UPMC Cancer Pavilion
5150 Centre Ave.
Pittsburgh PA
Research Interests and Keywords:
  • Medical oncology
  • clinical and translational research
  • sarcoma
  • immunotherapy
Summary

My research is focused on clinical and translational studies of soft tissue and bone sarcomas. Currently, I am investigating an immunotherapy utilizing an anti-PD1 inhibitor for patients with advanced sarcomas. In the future, I plan to further study novel immunotherapeutic approaches for advanced sarcomas, particularly with combinatorial strategies.

Lan Coffman, MD, PhD
Contact:
Magee-Womens Research Institute, B401
204 Craft Avenue
Pittsburgh PA
Phone: 412-641-2016
Umamaheswar (Uma) Duvvuri, MD, PhD
Contact:
Eye and Ear Institute, Suite 300
203 Lothrop Street
Pittsburgh PA
Research Interests and Keywords:
  • Otolaryngology
  • translational science of head and neck cancer
Annie Im, MD
Contact:
Cancer Pavilion, Rm 554
5150 Centre Ave.
Pittsburgh PA
Research Interests and Keywords:
  • Acute myeloid leukemia (AML)
  • epigenetics
  • hypomethylating agents
  • hematopoietic stem cell transplantation
  • chronic graft-versus-host disease (GVHD)
  • bronchiolitis obliterans syndrome
Summary

1) Acute myeloid leukemia (AML) in elderly patients: My research focuses on epigenetic strategies in the treatment of older patients with AML. We are running a clinical trial of a novel induction regimen using epigenetic priming by decitabine followed by cytarabine in older patients with newly diagnosed AML. Epigenetic correlatives studies are planned. 2) Epigenetic strategies to prevent relapse after hematopoietic stem cell transplant: I am interested in the role of epigenetic agents as immunomodulatory therapy to prevent relapse and graft-versus-host disease in patients with AML or MDS who are at high risk for relapse after allogeneic stem cell transplant. We are running a clinical trial using azacitidine maintenance therapy after allogeneic transplant for patients with AML and MDS. Correlative studies evaluating immune reconstitution and T-cell populations are planned. 3) Chronic graft-versus host disease (GVHD): I am interested in the study of chronic GVHD and long-term follow-up of allogeneic stem cell transplant patients. I work in collaboration with the Experimental Transplantation and Immunology Branch of the National Cancer Institute in the area of chronic GVHD. I study the natural history of chronic GVHD, as well as chronic GVHD-specific complications such as bronchiolitis obliterans syndrome.

Anuradha Krishnamurthy, MBBS, FRCPC
Yan Lin, PhD
Contact:
130 De Soto Street
Pittsburgh PA
Research Interests and Keywords:
  • Cancer bioinformatics
Priscilla McAuliffe, MD, PhD
Contact:
204 Craft Avenue
Pittsburgh PA
Alexander Olawaiye
Robert Redner, MD
Contact:
2.18A Hillman Research Pavilion
5117 Centre Avenue
Pittsburgh PA
Research Interests and Keywords:
  • Acute promyelocytic leukemia
  • acute myeloid leukemia
  • myelodysplastic syndromes
  • malignant and non-malignant hematology
Sarah Taylor, MD
Contact:
Magee-Womens Hospital of UPMC
300 Halket Street
Phone: (412) 641-5468
Nathan Bahary, MD, PhD
Contact:
UPMC Cancer Pavilion
5150 Centre Avenue, 5th Floor
Pittsburgh PA
Phone: 412-864-7764
Research Interests and Keywords:
  • Novel treatment strategies for GI cancers
  • developmental biology using the zebrafish model system
  • vasculogenesis
  • hematopoiesis
Alberto Broniscer, MD
David (Andy) Clump, MD, PhD
Contact:
UPMC Shadyside Hospital
Department of Radiation Oncology 5230 Centre Avenue, Posner Tower
Pittsburgh PA
Research Interests and Keywords:
  • Head and neck cancer
  • squamous cell carcinoma
  • stereotactic radiosurgery
  • IMRT
  • DNA damage repair
  • normal tissue protection
  • ATM
Summary

Dr. Clump specializes in integrating his clinical practice, which focuses on the treatment of head and neck malignancies as well as stereotactic radiosurgery, with his translational laboratory interests. As part of UPCI and UPMC CancerCenter, Dr. Clump is uniquely positioned to investigate the effects of radiation on both tumor as well as normal tissues. In this regard, he studies the DNA damage response following radiation therapy and is examining the effects of these cellular changes on tumor control as well as systemic effects.

Sanja Dacic, MD, PhD
Contact:
Rm. PUH C608
UPMC-PUH 200 Lothrop St.
Pittsburgh PA
Research Interests and Keywords:
  • Lung neoplasms
  • biological tumor markers
Jan Drappatz, MD
Contact:
UPMC Cancer Pavilion
5150 Center Ave
Pittsburgh PA
Research Interests and Keywords:
  • CNS tumors
  • brain tumors
  • glioma
  • glioblastoma
  • angiogenesis inhibitors
  • targeted therapies
  • immunotherapy
  • neurologic complications of cancer
  • prognostic biomarkers
Summary

My research is directed towards the development of new therapies for primary and secondary brain tumors using targeted drugs, inhibitors of angiogenesis, and immunotherapies. I am also interested in the identification of molecular markers of prognosis in patients with malignant glioma and other primary brain tumors.

Vikram Gorantla, MD
Seungwon (Steve) Kim, PhD
Contact:
200 Lothrop Street
EEI, Suite 500
Pittsburgh PA
Research Interests and Keywords:
  • Squamous cell carcinoma
  • head and neck neoplasms
Frank Lieberman, MD
Contact:
Department of Neurology
811 Kaufmann Medical Building 3471 Fifth Avenue
Pittsburgh PA
Research Interests and Keywords:
  • Neuro-oncology
  • molecular genetics and molecular neuropathology in diagnosis, prognosis, and management of CNS neoplasms
Megan Mantica, MD
Contact:
Hillman Cancer Center
5115 Centre Ave., 2nd Floor
Pittsburgh PA
Phone: (412)-692-4724
Summary

Dr. Mantica specializes in the treatment of adult high grade gliomas, central nervous system lymphoma, and neurological complications of cancer treatment. Her translational research interests include women’s neuro-oncology, metastatic brain disease and high grade gliomas.

Daniel Normolle, PhD
Contact:
130 De Soto Street
Pittsburgh PA
Research Interests and Keywords:
  • Biostatistics
  • design of dose-escalation trials
  • biomarker adaptive clinical trials
Priya Rastogi, MD
Contact:
UPMC CancerCenter at Magee-Womens Hospital of UPMC
300 Halket Street
Pittsburgh PA
Research Interests and Keywords:
  • Breast cancer
  • medical oncology
D. Lansing Taylor, PhD
Contact:
10045 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh PA
Liza Villaruz, MD
Contact:
UPMC Cancer Pavilion
5150 Centre Avenue 5th Floor
Pittsburgh PA
Research Interests and Keywords:
  • Clinical trials in lung cancer
  • novel therapeutics
Antoinette Wozniak, MD
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