I have conducted behavioral research in a variety of cancer populations including breast, gynecologic, head and neck, and hematological malignancies. I currently hold an NCI K23 Career Development Award examining adherence to the medical regimen for hematological cancer patients who are post allogeneic hematopoietic cell transplantation (HCT) and their family caregivers.
Allogeneic HCT is a potentially curative therapy for hematologic disease, but is associated with multiple complications and significant stress to patients and family caregivers (CGs). To enhance outcomes and minimize risks, patients and CGs must work together as a team to carefully adhere to the multi-component post-HCT medical regimen, consisting of multiple daily medications, frequent clinic visits, strict catheter care, health monitoring, and dietary and lifestyle restrictions.
Despite the clinical importance of adherence to the post-HCT regimen, particularly during the critical first 100 days post HCT, little research has examined rates or risk factors for nonadherence in this population, or how HCT patients and family caregivers manage each component of the post-HCT regimen together. Further, it is important to develop strategies to help patients and family caregivers better adhere to the regimen. Problem-Solving Therapy (PST), an evidenced-based clinical intervention to enhance coping strategies, will be the basis to build a novel patient-caregiver dyadic intervention for the HCT population.