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Discovery of Novel Risk and Causative Factors for Cancer investigators

Wendie Berg

Wendie Berg

Program: Cancer Epidemiology and Prevention

(412) 641-1635 bergwa@upmc.edu UPMC Magee-Womens Hospital
300 Halket St.
Pittsburgh PA
Research Interests and Keywords
  • Comparative effectiveness of new technologies in breast imaging,Comparison of tomosynthesis and ultrasound for cancer detection,Risk assessment and breast density,Supplemental screening for breast cancer based on risk
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Jane Cauley

Jane Cauley

Program: Cancer Epidemiology and Prevention

jcauley@pitt.edu 130 De Soto Street, A533 Crabtree Hall
Pittsburgh PA
Summary

Dr. Cauley's primary research interest is the epidemiology of osteoporosis, osteoporosis treatment and the consequences of osteoporosis in both men and women. She also has a major interest in breast cancer and served on the American Society of Clinical Oncology Writing Group about the use of bisphosphonates in women with breast cancer. Her other research has focused on women's health and aging, falls, the interaction between endogenous and exogenous hormones, risk factors, inflammation, and disease outcomes. She examines the physical and psychological changes that occur in postmenopausal women.

Research Interests and Keywords
  • Breast Cancer,Epidemiology,Osteoporosis,sex hormones
Read More about Jane Cauley
Brenda Diergaarde

Brenda Diergaarde

Program: Cancer Epidemiology and Prevention

412-623-5891 diergaardeb@upmc.edu UPMC Cancer Pavilion
5150 Centre Ave, Suite 4C
Pittsburgh PA
Summary

Dr. Diergaarde's research examines the role of diet, lifestyle and genetic variation in the development, progression and treatment of cancer, including cancers of the lung, head and neck, colon, ovaries and breast, and aims to identify markers for risk stratification, early detection and response to treatment. She is currently Co-Leader of Project 2 of the UPCI Specialized Program of Research Excellence (SPORE) in Lung Cancer. This project seeks to establish the relationship between vitamin D exposure, pulmonary inflammation and lung cancer risk and so provide strong rationale for a vitamin D-based approach to lung cancer prevention. She is also Leader of Project 1 of the UPCI SPORE in Head and Neck Cancer. Using data and samples from a large, clinic-based case-control study, this project investigates the role of genetic variation and gene-environment interactions in the development, progression and treatment of head and neck squamous cell carcinoma.

Research Interests and Keywords
  • Biomarkers,cancer epidemiology,Cancer prevention,Diet,Genetic Variation,head and neck cancer,lifestyle,Lung Cancer,Molecular Epidemiology
Read More about Brenda Diergaarde
James Herman

James Herman

Program: Cancer Epidemiology and Prevention

hermanj3@upmc.edu Hillman Cancer Center, 2.18d
Pittsburgh PA
Research Interests and Keywords
  • Biomarkers,cancer prognosis,DNA Methylation,early detection,Epigenetics,Lung Cancer,Transcription Factors,tumor suppressor genes
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Jing Hu

Jing Hu

Program: Cancer Epidemiology and Prevention

huj3@upmc.edu 5117 Centre Avenue, Suite 2.32B
Pittsburgh PA
Research Interests and Keywords
  • Cancer Biology,Histone Deacetylases,post-translational modifications,Protein kinases and phosphatases,sumoylation
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Hung Luu

Hung Luu

Program: Cancer Epidemiology and Prevention

Read More about Hung Luu
Phuong Mai

Phuong Mai

Program: Cancer Epidemiology and Prevention

Read More about Phuong Mai
Francesmary Modugno

Francesmary Modugno

Program: Cancer Epidemiology and Prevention

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Robert Schoen

Robert Schoen

Program: Cancer Epidemiology and Prevention

schoen@msx.dept-med.pitt.edu PUH - Mezz. 2 - C Wing
200 Lothrop Street
Pittsburgh PA
Research Interests and Keywords
  • acceptability and implementation of CRC screening,Early detection and prevention of colorectal cancer (CRC),flexible sigmoidoscopy,surveillance colonoscopy
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Evelyn Talbott

Evelyn Talbott

Program: Cancer Epidemiology and Prevention

412-624-3074 eot1@pitt.edu A526 Crabtree Hall
Pittsburgh PA
Summary

Dr. Talbott's areas of expertise are in environmental and cardiovascular epidemiology. Dr. Talbott has worked closely with both state and local health departments to conduct health studies investigating potential linkage of environmental exposures and health effects.

Research Interests and Keywords
  • environmental epidemiology
Read More about Evelyn Talbott
David Whitcomb

David Whitcomb

Program: Cancer Epidemiology and Prevention

whitcomb@pitt.edu Mezzanine Level
C-Wing-PUH 200 Lothrop Street
Pittsburgh PA
Research Interests and Keywords
  • and pancreatic cancer,chronic pancreatitis,Mechanisms of complex disorders including acute pancreatitis
Read More about David Whitcomb
David Wilson

David Wilson

Program: Cancer Epidemiology and Prevention

412-687-3355 wilsondo@upmc.edu 5150 Centre Ave. Ste. 4c
Pittsburgh PA
Summary

Dr. Wilson's research interests include: lung cancer screening and chemoprevention, diagnosis, staging and treatment; COPD, especially as it relates to lung cancer; occupational lung diseases; and general pulmonary medicine.

Research Interests and Keywords
  • Chemoprevention,COPD,Diagnosis,lung cancer screening,pulmonary medicine,staging and treatment
Read More about David Wilson
Jian-Min Yuan

Jian-Min Yuan

Program: Cancer Epidemiology and Prevention

412-864-7889 yuanj@upmc.edu UPMC Cancer Pavilion
5150 Centre Avenue - Suite 4C Office 470
Pittsburgh PA
Summary

Dr. Yuan is a cancer epidemiologist with extensive experience in research on cancer etiology and prevention. Dr. Yuan is Principal Investigator of the Shanghai Cohort Study and the Singapore Chinese Health Study, two population-based prospective cohorts of more than 80,000 Chinese men and women with available baseline blood and urine samples with more than 25 years of active follow-up for cancer and other major health outcomes.

Utilizing these two large cohort resources coupled with a biomarker approach, Dr. Yuan and his research team have made several noteworthy contributions to the field of cancer epidemiology including (1) dietary aflatoxins as human hepatocarcinogens, (2) dietary isothiocyanates, a group of phytochemicals found in cruciferous vegetables, as potential chemopreventive agents against lung cancer development, and (3) urinary biomarkers of nicotine, tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons as risk predictors for lung cancer in smokers.

 

Dr. Yuan also has extensive experience in designing and conducting randomized, double-blind intervention studies on cancer prevention. Dr. Yuan is leading the effort to conduct a randomized, double-blind phase II clinical trial to evaluate the effectiveness of dietary 2-phenethyl isothiocyanates (PEITC) supplementation on reduction of risk markers for lung cancer in smokers. In addition, Dr. Yuan, collaborating with Dr. Mindy Kurzer, his former colleague at the University of Minnesota, is conducting a randomized, double-blind phase II clinical trial to evaluate the efficacy of oral supplementation of green tea extracts (Polyphenon E) on reduction of risk markers for breast cancer in women.

Research Interests and Keywords
  • cancer biomarkers,cancer epidemiology,Cancer prevention,cancer risk prediction,Clinical Trials,dietary chemopreventive agents,Gene-environment interaction in cancer etiology
Read More about Jian-Min Yuan

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