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Da Yang, MD, PhD
Program(s): Cancer Biology
Contact:
308 Pavilion
Pittsburgh PA
Phone: 412-383-5145
Research Interests and Keywords:
  • Drug resistance
  • genomics
  • epigenetics
  • cancer therapeutics
  • biomarkers
  • personalized cancer medicine
Summary
The research of Dr. Yang's laboratory focuses on using integrated genomic and functional studies to identify mechanisms of resistance to cancer therapeutics, and to develop novel approaches and biomarkers to enable personalized cancer medicine. Currently, ongoing work involves: 1) mechanistic studies of resistance to cancer therapeutics, especially targeted therapy for pathways with the most prevalent genomic alterations in human solid tumors; and 2) characterization of genetic and epigenetic alterations of non protein-coding components (ncRNAs) of the genome, such as miRNA and lncRNA genes in solid tumors. His approaches have proved successful in several instances, including the identification of miR-506 as a tumor suppressor that inhibits epithelial-to-mesenchymal transition (EMT) and cell cycle pathways, and the discovery of BRCA2 gene mutations that lead to genome instability and cisplatin response in ovarian cancer.
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