Frank Jenkins, PhD

Summary

Kaposi's sarcoma-associated herpesvirus (KSHV), or HHV-8, is a member of the human herpesvirus family whose DNA sequences have been found in samples of Kaposi's sarcoma (KS). A number of projects in our laboratory are focused on the prevalence of KSHV infection in various cohorts and populations. We are particularly interested in the serological association of KSHV with human prostate cancer and are investigating at a molecular level, potential roles for KSHV in progression and maintenance of this cancer. We are also exploring the events during primary KSHV infection, including interactions between the virus and cell membrane, modulation of host gene synthesis, and establishment of viral infection. My lab has also been involved for several years in biobehavioral medicine. Specifically, we are interested in the role of stress and stress hormones in disease pathogenesis. Our current studies involve how stress hormones affect individual cells, the types of damage they may inflict on these cells and the outcomes of these interactions.