Selected Member Publications

. Pathological polyploidy and liver repair failure in RAD51-deficient mice. Hepatology. 2025-02-01; doi: 10.1097/HEP.0000000000000871. nihFormattedCitation: Duncan AW. Pathological polyploidy and liver repair failure in RAD51-deficient mice. Hepatology. 2025;.. PubMed PMID: 38546299.
. Unlocking transcription-coupled DNA repair with the STK19 key. Mol Cell. 2024-12-19;84(24):4693-4695. doi: 10.1016/j.molcel.2024.11.027. nihFormattedCitation: Kuper J, Kisker C, Van Houten B. Unlocking transcription-coupled DNA repair with the STK19 key. Mol Cell. 2024;84(24):4693-4695.. PubMed PMID: 39706162.
. Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial. Lancet. 2024-11-23; doi: 10.1016/S0140-6736(24)01812-9. nihFormattedCitation: Mowery YM, Ballman KV, Hong AM, Schuetze SM, Wagner AJ, Monga V, Heise RS, Attia S, Choy E, Burgess MA, Bae S, Pryor DI, Van Tine BA, Tinoco G, Chmielowski B, Freeman C, Gronchi A, Meyer CF, Dickson MA, Hartner L, Davis LE, Powers BC, Moding EJ, Weinhold KJ, van de Rijn M, Brigman BE, Riedel RF, Kirsch DG. Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial. Lancet. 2024;.. PubMed PMID: 39547252.
. Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine. Nat Commun. 2024-10-25;15(1):9226. doi: 10.1038/s41467-024-53497-7. nihFormattedCitation: Schnable BL, Schaich MA, Roginskaya V, Leary LP, Weaver TM, Freudenthal BD, Drohat AC, Van Houten B. Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine. Nat Commun. 2024;15(1):9226. PMCID: PMC11512004.. PubMed PMID: 39455577; PMCID: PMC11512004.
. NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance. Clin Cancer Res. 2024-09-13; doi: 10.1158/1078-0432.CCR-24-1363. nihFormattedCitation: Mowery YM, Luke JJ. NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance. Clin Cancer Res. 2024;. PMCID: PMC11398986.. PubMed PMID: 39007757; PMCID: PMC11398986.
. A persistent variant telomere sequence in a human pedigree. Nat Commun. 2024-06-01;15(1):4681. doi: 10.1038/s41467-024-49072-9. nihFormattedCitation: Hinchie AM, Sanford SL, Loughridge KE, Sutton RM, Parikh AH, Gil Silva AA, Sullivan DI, Chun-On P, Morrell MR, McDyer JF, Opresko PL, Alder JK. A persistent variant telomere sequence in a human pedigree. Nat Commun. 2024;15(1):4681. PMCID: PMC11144197.. PubMed PMID: 38824190; PMCID: PMC11144197.
. Deregulated DNA ADP-ribosylation impairs telomere replication. Nat Struct Mol Biol. 2024-05-01; doi: 10.1038/s41594-024-01279-6. nihFormattedCitation: Wondisford AR, Lee J, Lu R, Schuller M, Groslambert J, Bhargava R, Schamus-Haynes S, Cespedes LC, Opresko PL, Pickett HA, Min J, Ahel I, O'Sullivan RJ. Deregulated DNA ADP-ribosylation impairs telomere replication. Nat Struct Mol Biol. 2024;. PMCID: PMC11102865.. PubMed PMID: 38714889; PMCID: PMC11102865.
. PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress. Nat Commun. 2024-04-02;15(1):2857. doi: 10.1038/s41467-024-47222-7. nihFormattedCitation: Muoio D, Laspata N, Dannenberg RL, Curry C, Darkoa-Larbi S, Hedglin M, Uttam S, Fouquerel E. PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress. Nat Commun. 2024;15(1):2857. PMCID: PMC10987537.. PubMed PMID: 38565848; PMCID: PMC10987537.
. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024-03-01; doi: 10.1038/s41388-024-02939-z. nihFormattedCitation: Chao Y, Chen Y, Zheng W, Demanelis K, Liu Y, Connelly JA, Wang H, Li S, Wang QJ. Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer. Oncogene. 2024;. PMCID: PMC11556418.. PubMed PMID: 38273024; PMCID: PMC11556418.
. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024-02-28; doi: 10.1093/nar/gkad1209. nihFormattedCitation: Johnson SA, Paul T, Sanford SL, Schnable BL, Detwiler AC, Thosar SA, Van Houten B, Myong S, Opresko PL. BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions. Nucleic Acids Res. 2024;. PMCID: PMC10939409.. PubMed PMID: 38153143; PMCID: PMC10939409.
. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Rep. 2024-01-23;43(1):113656. doi: 10.1016/j.celrep.2023.113656. nihFormattedCitation: Thosar SA, Barnes RP, Detwiler A, Bhargava R, Wondisford A, O'Sullivan RJ, Opresko PL. Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair. Cell Rep. 2024;43(1):113656. PMCID: PMC10851105.. PubMed PMID: 38194346; PMCID: PMC10851105.
. FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner. Clin Cancer Res. 2024-01-05;30(1):187-197. doi: 10.1158/1078-0432.CCR-23-0964. nihFormattedCitation: Pifer PM, Yang L, Kumar M, Xie T, Frederick M, Hefner A, Beadle B, Molkentine D, Molkentine J, Dhawan A, Abdelhakiem M, Osman AA, Leibowitz BJ, Myers JN, Pickering CR, Sandulache VC, Heymach J, Skinner HD. FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner. Clin Cancer Res. 2024;30(1):187-197. PMCID: PMC10767302.. PubMed PMID: 37819945; PMCID: PMC10767302.
. LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging. Blood. 2023-11-02; doi: 10.1182/blood.2022018212. nihFormattedCitation: Wu L, Lin Q, Chatla S, Amarachintha SP, Wilson AF, Atale N, Gao ZJ, Joseph J, Wolff E, Du W. LepR+ niche cell-derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging. Blood. 2023;. PMCID: PMC10656728.. PubMed PMID: 37584437; PMCID: PMC10656728.
. Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. Redox Biol. 2023-10-01;66102856. doi: 10.1016/j.redox.2023.102856. nihFormattedCitation: Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. Redox Biol. 2023;66:102856. PMCID: PMC10472314.. PubMed PMID: 37633047; PMCID: PMC10472314.
. A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early Detection of Pancreatic Cancer Arising From Pancreatic Cysts. Ann Surg. 2023-10-01;278(4):e789-e797. doi: 10.1097/SLA.0000000000005904. nihFormattedCitation: Nikiforova MN, Wald AI, Spagnolo DM, Melan MA, Grupillo M, Lai YT, Brand RE, O'Broin-Lennon AM, McGrath K, Park WG, Pfau PR, Polanco PM, Kubiliun N, DeWitt J, Easler JJ, Dam A, Mok SR, Wallace MB, Kumbhari V, Boone BA, Marsh W, Thakkar S, Fairley KJ, Afghani E, Bhat Y, Ramrakhiani S, Nasr J, Skef W, Thiruvengadam NR, Khalid A, Fasanella K, Chennat J, Das R, Singh H, Sarkaria S, Slivka A, Gabbert C, Sawas T, Tielleman T, Vanderveldt HD, Tavakkoli A, Smith LM, Smith K, Bell PD, Hruban RH, Paniccia A, Zureikat A, Lee KK, Ongchin M, Zeh H, Minter R, He J, Nikiforov YE, Singhi AD. A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early Detection of Pancreatic Cancer Arising From Pancreatic Cysts. Ann Surg. 2023;278(4):e789-e797. PMCID: PMC10481930.. PubMed PMID: 37212422; PMCID: PMC10481930.
. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023-07-25;120(30):e2308010120. doi: 10.1073/pnas.2308010120. nihFormattedCitation: Wan L, Toland S, Robinson-McCarthy LR, Lee N, Schaich MA, Hengel SR, Li X, Bernstein KA, Van Houten B, Chang Y, Moore PS. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023;120(30):e2308010120. PMCID: PMC10372695.. PubMed PMID: 37459531; PMCID: PMC10372695.
. Spatial mapping of cellular senescence: emerging challenges and opportunities. Nat Aging. 2023-07-01;3(7):776-790. doi: 10.1038/s43587-023-00446-6. nihFormattedCitation: Gurkar AU, Gerencser AA, Mora AL, Nelson AC, Zhang AR, Lagnado AB, Enninful A, Benz C, Furman D, Beaulieu D, Jurk D, Thompson EL, Wu F, Rodriguez F, Barthel G, Chen H, Phatnani H, Heckenbach I, Chuang JH, Horrell J, Petrescu J, Alder JK, Lee JH, Niedernhofer LJ, Kumar M, Königshoff M, Bueno M, Sokka M, Scheibye-Knudsen M, Neretti N, Eickelberg O, Adams PD, Hu Q, Zhu Q, Porritt RA, Dong R, Peters S, Victorelli S, Pengo T, Khaliullin T, Suryadevara V, Fu X, Bar-Joseph Z, Ji Z, Passos JF. Spatial mapping of cellular senescence: emerging challenges and opportunities. Nat Aging. 2023;3(7):776-790. PMCID: PMC10505496.. PubMed PMID: 37400722; PMCID: PMC10505496.
. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators. Proc Natl Acad Sci U S A. 2023-06-20;120(25):e2218896120. doi: 10.1073/pnas.2218896120. nihFormattedCitation: Dar HH, Mikulska-Ruminska K, Tyurina YY, Luci DK, Yasgar A, Samovich SN, Kapralov AA, Souryavong AB, Tyurin VA, Amoscato AA, Epperly MW, Shurin GV, Standley M, Holman TR, St Croix CM, Watkins SC, VanDemark AP, Rana S, Zakharov AV, Simeonov A, Marugan J, Mallampalli RK, Wenzel SE, Greenberger JS, Rai G, Bayir H, Bahar I, Kagan VE. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators. Proc Natl Acad Sci U S A. 2023;120(25):e2218896120. PMCID: PMC10288584.. PubMed PMID: 37327313; PMCID: PMC10288584.
. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023-06-09;51(10):4881-4898. doi: 10.1093/nar/gkad206. nihFormattedCitation: Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023;51(10):4881-4898. PMCID: PMC10250209.. PubMed PMID: 36971122; PMCID: PMC10250209.
. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2023-06-09;51(10):4814-4830. doi: 10.1093/nar/gkad180. nihFormattedCitation: Ellison MA, Namjilsuren S, Shirra MK, Blacksmith MS, Schusteff RA, Kerr EM, Fang F, Xiang Y, Shi Y, Arndt KM. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2023;51(10):4814-4830. PMCID: PMC10250246.. PubMed PMID: 36928138; PMCID: PMC10250246.
. Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6. Proc Natl Acad Sci U S A. 2023-05-30;120(22):e2220041120. doi: 10.1073/pnas.2220041120. nihFormattedCitation: Fetian T, McShane BM, Horan NL, Shodja DN, True JD, Mosley AL, Arndt KM. Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6. Proc Natl Acad Sci U S A. 2023;120(22):e2220041120. PMCID: PMC10235976.. PubMed PMID: 37216505; PMCID: PMC10235976.
. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023-05-01;61102650. doi: 10.1016/j.redox.2023.102650. nihFormattedCitation: Tyurina YY, Kapralov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023;61:102650. PMCID: PMC9996109.. PubMed PMID: 36870109; PMCID: PMC9996109.
. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023-04-24;51(7):e39. doi: 10.1093/nar/gkad095. nihFormattedCitation: Schaich MA, Schnable BL, Kumar N, Roginskaya V, Jakielski RC, Urban R, Zhong Z, Kad NM, Van Houten B. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE). Nucleic Acids Res. 2023;51(7):e39. PMCID: PMC10123111.. PubMed PMID: 36861323; PMCID: PMC10123111.
. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023-03-21;51(5):2215-2237. doi: 10.1093/nar/gkad066. nihFormattedCitation: Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023;51(5):2215-2237. PMCID: PMC10018367.. PubMed PMID: 36794853; PMCID: PMC10018367.
. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022-12-09;50(22):12856-12871. doi: 10.1093/nar/gkac1145. nihFormattedCitation: Jang S, Kumar N, Schaich MA, Zhong Z, van Loon B, Watkins SC, Van Houten B. Cooperative interaction between AAG and UV-DDB in the removal of modified bases. Nucleic Acids Res. 2022;50(22):12856-12871. PMCID: PMC9825174.. PubMed PMID: 36511855; PMCID: PMC9825174.
. TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science. 2022-11-11;378(6620):664-668. doi: 10.1126/science.abq0607. nihFormattedCitation: Chun-On P, Hinchie AM, Beale HC, Gil Silva AA, Rush E, Sander C, Connelly CJ, Seynnaeve BKN, Kirkwood JM, Vaske OM, Greider CW, Alder JK. TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science. 2022;378(6620):664-668. PMCID: PMC10590476.. PubMed PMID: 36356143; PMCID: PMC10590476.
. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022-11-03;82(21):4001-4017.e7. doi: 10.1016/j.molcel.2022.09.025. nihFormattedCitation: Kaminski N, Wondisford AR, Kwon Y, Lynskey ML, Bhargava R, Barroso-González J, García-Expósito L, He B, Xu M, Mellacheruvu D, Watkins SC, Modesti M, Miller KM, Nesvizhskii AI, Zhang H, Sung P, O'Sullivan RJ. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022;82(21):4001-4017.e7. PMCID: PMC9713952.. PubMed PMID: 36265488; PMCID: PMC9713952.
. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022-10-01;56102443. doi: 10.1016/j.redox.2022.102443. nihFormattedCitation: Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022;56:102443. PMCID: PMC9450138.. PubMed PMID: 36058112; PMCID: PMC9450138.
. Telomere-mediated lung disease. Physiol Rev. 2022-10-01;102(4):1703-1720. doi: 10.1152/physrev.00046.2021. nihFormattedCitation: Alder JK, Armanios M. Telomere-mediated lung disease. Physiol Rev. 2022;102(4):1703-1720. PMCID: PMC9306791.. PubMed PMID: 35532056; PMCID: PMC9306791.
. Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening. Nat Struct Mol Biol. 2022-07-01;29(7):639-652. doi: 10.1038/s41594-022-00790-y. nihFormattedCitation: Barnes RP, de Rosa M, Thosar SA, Detwiler AC, Roginskaya V, Van Houten B, Bruchez MP, Stewart-Ornstein J, Opresko PL. Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening. Nat Struct Mol Biol. 2022;29(7):639-652. PMCID: PMC9287163.. PubMed PMID: 35773409; PMCID: PMC9287163.
. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest. 2022-06-15;132(12): doi: 10.1172/JCI155914. nihFormattedCitation: Lin Q, Wu L, Chatla S, Chowdhury FA, Atale N, Joseph J, Du W. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest. 2022;132(12). PMCID: PMC9197516.. PubMed PMID: 35703178; PMCID: PMC9197516.
. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022-04-01;82(7):1340-1352. doi: 10.1158/0008-5472.CAN-21-3062. nihFormattedCitation: Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022;82(7):1340-1352. PMCID: PMC8983601.. PubMed PMID: 35149588; PMCID: PMC8983601.
. Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biol. 2022-04-01;50102232. doi: 10.1016/j.redox.2022.102232. nihFormattedCitation: Lamade AM, Wu L, Dar HH, Mentrup HL, Shrivastava IH, Epperly MW, St Croix CM, Tyurina YY, Anthonymuthu TS, Yang Q, Kapralov AA, Huang Z, Mao G, Amoscato AA, Hier ZE, Artyukhova MA, Shurin G, Rosenbaum JC, Gough PJ, Bertin J, VanDemark AP, Watkins SC, Mollen KP, Bahar I, Greenberger JS, Kagan VE, Whalen MJ, Bayır H. Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biol. 2022;50:102232. PMCID: PMC8804265.. PubMed PMID: 35101798; PMCID: PMC8804265.
. Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probe. Sci Adv. 2022-03-04;8(9):eabm8293. doi: 10.1126/sciadv.abm8293. nihFormattedCitation: Xu J, Sun X, Kim K, Brand RM, Hartman D, Ma H, Brand RE, Bai M, Liu Y. Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probe. Sci Adv. 2022;8(9):eabm8293. PMCID: PMC8896800.. PubMed PMID: 35245126; PMCID: PMC8896800.
. p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022-03-01;82(5):916-928. doi: 10.1158/0008-5472.CAN-21-2101. nihFormattedCitation: Molkentine DP, Molkentine JM, Bridges KA, Valdecanas DR, Dhawan A, Bahri R, Hefner AJ, Kumar M, Yang L, Abdelhakiem M, Pifer PM, Sandulache V, Sheth A, Beadle BM, Thames HD, Mason KA, Pickering CR, Meyn RE, Skinner HD. p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade. Cancer Res. 2022;82(5):916-928. PMCID: PMC9136619.. PubMed PMID: 34965932; PMCID: PMC9136619.
. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022-02-21;13(1):974. doi: 10.1038/s41467-022-28642-9. nihFormattedCitation: Kumar N, Theil AF, Roginskaya V, Ali Y, Calderon M, Watkins SC, Barnes RP, Opresko PL, Pines A, Lans H, Vermeulen W, Van Houten B. Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins. Nat Commun. 2022;13(1):974. PMCID: PMC8861037.. PubMed PMID: 35190564; PMCID: PMC8861037.
. Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60. Sci Adv. 2022-02-18;8(7):eabl6083. doi: 10.1126/sciadv.abl6083. nihFormattedCitation: Hamsanathan S, Anthonymuthu T, Han S, Shinglot H, Siefken E, Sims A, Sen P, Pepper HL, Snyder NW, Bayir H, Kagan V, Gurkar AU. Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60. Sci Adv. 2022;8(7):eabl6083. PMCID: PMC8849393.. PubMed PMID: 35171671; PMCID: PMC8849393.
. Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. Gastroenterology. 2022-01-01;162(1):46-48. doi: 10.1053/j.gastro.2021.09.065. nihFormattedCitation: Wilson SR, Duncan AW. Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. Gastroenterology. 2022;162(1):46-48. PMCID: PMC8981166.. PubMed PMID: 34626601; PMCID: PMC8981166.
. TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 2021-12-16;49(22):13000-13018. doi: 10.1093/nar/gkab1142. nihFormattedCitation: Kaur P, Barnes R, Pan H, Detwiler AC, Liu M, Mahn C, Hall J, Messenger Z, You C, Piehler J, Smart RC, Riehn R, Opresko PL, Wang H. TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 2021;49(22):13000-13018. PMCID: PMC8682769.. PubMed PMID: 34883513; PMCID: PMC8682769.
. Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021-11-26;12(1):6936. doi: 10.1038/s41467-021-27300-w. nihFormattedCitation: Wu L, Chatla S, Lin Q, Chowdhury FA, Geldenhuys W, Du W. Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021;12(1):6936. PMCID: PMC8626516.. PubMed PMID: 34836965; PMCID: PMC8626516.
. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021-11-03;12(1):6340. doi: 10.1038/s41467-021-26570-8. nihFormattedCitation: Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021;12(1):6340. PMCID: PMC8566594.. PubMed PMID: 34732714; PMCID: PMC8566594.
. Interferon b drives intestinal regeneration after radiation. Sci Adv. 2021-10-08;7(41):eabi5253. doi: 10.1126/sciadv.abi5253. nihFormattedCitation: Leibowitz BJ, Zhao G, Wei L, Ruan H, Epperly M, Chen L, Lu X, Greenberger JS, Zhang L, Yu J. Interferon b drives intestinal regeneration after radiation. Sci Adv. 2021;7(41):eabi5253. PMCID: PMC8494436.. PubMed PMID: 34613772; PMCID: PMC8494436.
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