Investigators

Summary

Innate immunity of an organism is the inborn protection against invading pathogens. We are interested in the host innate immune response during virus infection and cancer. Although several basic principles of virus detection and host signaling have been identified, the specific mechanisms by which these pathways are modulated by host components during microbial infection or tumor progression remains poorly understood. Following are some of the specific research topic we are interested:

1. Signaling mechanisms of type I Interferon (IFN) induction and modulation during DNA and RNA virus infection. 
2. Mechanism of antiviral and antibacterial activity of IFN-stimulated genes (ISGs), such as IFN-inducible Oligoadenylate synthetase (OAS) family genes. 
3. Differential roles of IFN-regulatory factors (IRFs) in tumor progression and immunotherapy of cancer.