UPMC Hillman Cancer Center Biostatistics Services & Equipment

The BF provides statistical expertise in study design and data analysis for members of UPMC Hillman Cancer Center. Statisticians within the unit collaborate on developing protocols for clinical trials, and research proposals for laboratory-based investigations, epidemiologic studies, and clinical investigations. We perform statistical analyses for such studies, substantively interpret their results and author or co-author papers for publication. The BF is committed to developing statistical methodology that aids cancer research, and to applying statistical and computational methods to accomplish this.

Study design

  • Advise on statistical aspects of the design of laboratory-based studies, clinical trials, clinical investigations, epidemiologic studies, and population-based studies such as screening programs
  • Formulate study objectives and endpoints in terms that are appropriate for statistical analysis
  • Recommend and implement novel statistical methods, such as adaptive dose-finding techniques for phase I clinical trials
  • Propose and implement alternative designs for phase II clinical trials
  • Determine sample size needed to address study objectives at an appropriate level of significance, power or false-discovery rate
  • Develop and write plans for statistical analyses
  • Develop and implement randomization procedures

Data analysis

  • Analysis of diagnostic & screening tests
  • Assessment of prognostic markers
  • Bayesian estimation
  • Evaluation of cancer patients’ quality of life in clinical trials
  • Interim monitoring of clinical trials using frequentist or Bayesian methodology
  • Kaplan-Meier estimation
  • Linear, nonlinear and multiple regression
  • Logistic, polytomous, and Poisson regression
  • Logic regression
  • Meta-analysis
  • Mixed models
  • Nonparametric estimation
  • Proportional hazards regression
  • Repeated measures analysis

Grant Proposals, Manuscripts and Presentations

  • Write analysis plans and design justifications for clinical and preclinical experiments
  • Review study objectives and align them with analysis plans and experimental designs
  • Scientific editing
  • Write Statistical Methods and Results sections of manuscripts and posters
  • Graphics for manuscripts, posters and presentations


Each biostatistician has a workstation equipped with the latest software for statistical analysis (SAS, R, S-Plus, StatXact, Stata, NCSS/PASS) and office productivity (LaTeX, Access, Excel, Outlook, PowerPoint, Word, MathType, Reference Manager). Their workstations are linked through a firewall-protected local area network with local servers providing data backup, file sharing, and network printing services. One server supports legacy statistical applications, a web-enabled patient randomization service, and a shared web/ftp server. Finally, all workstations have a wide-area network connection that provides a connection to the internet and online access to resources of the University of Pittsburgh and UPMC.

Beginning in 2012, the BF also supports a legacy data system for raw data, analysis code, analysis results, graphics and reports associated with peer-reviewed publications.

The BF no longer supports the Java Bryant-Day clinical trial design tool. The function freq_binom_two_bryantday_twostage in the R package EurosarcBayes, available from CRAN, provides these designs.